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Table 2 Clinical characteristics of 3 cycles

From: Rare homozygous mutation in TUBB8 associated with oocyte maturation defect-2 in a consanguineous mating family

Cycle number

Date/Menstrual cycle

Medicine

Follicles of right ovary (mm(N))

Follicles of left ovary (mm(N))

Total Number of oocyte retrieved

Stage of Oocyte (N) after 24–36 h of culture in vitro

1

    

23

MI(22) + GV(1)

2017.10.25/D18

GnRHa (mg):0.9

    

2017.11.8/D5

rFSH(U): 150*5d

2*2(3)

2*2(4)

  

2017.11.13/D10

rFSH(U): 150*4d

8*8(3),6*6(3)

10*9(2),8*7(1),7*5(3)

  

2017.11.17/D14

rFSH(U): 150*3d

15*14(1),14*14(1),12*11(4)

15*15(1),15*13(2),16*12(1), 14*14(2),14*10(1),12*12(2)

  

2017.11.20/D17

rHCG (ug): 250

21*21(1)

22*19(1),21*20(2),19*17(2), 19*16(2),18*17(1)

  

2

    

21

MI(12) + GV(2)+ + degenerate oocytes (7)

2018.3.19/D3

HMG(U): 225*5d

Clomiphene citrate (mg): 100*5d

5–6(3–6)

6–7(3–6)

  

2018.3.24/D8

HMG(U): 225

Clomiphene citrate (mg): 100

16*13(1),14*13(1),13*12(1)

15*11(2)

  

2018.3.25/D9

HMG(U): 225*2d

Clomiphene citrate (mg): 100*2d

Ganirelix (mg): 0.25*2d

    

2018.3.27/D11

HMG(U): 225

Ganirelix (mg): 0.25

23*21(1),20*17(1),18*15(2),17*17(2),17*15(2)

20*17(2),18*14(2),17*12(2)

  

2018.3.28/D12

Ganirelix (mg): 0.25

HCG (IU):8000

22*22(1),21*20(1),20*20(3),19*19(2),18*18(2)

23*17(1),22*20(1),18*18(1), 17*17(1)

  

3

    

12

MI(7) + GV(3) + degenerate oocytes(2)

2018.9.18/D3

HMG(U): 225*4d

3–4(6)

3–4(7)

  

2018.9.22/D7

HMG(U): 225*2d

8*8(1),6*5(1),5*5(1),4*4(1),4*3(1)

10*7(1),9*9(1),9*7(1),8*8(1)

  

2018.9.24/D9

HCG(U): 10000

13*12(1),8*8(2),7*7(1),5*5(4)

13*13(1),13*12(1),12*12(1), 11*11(1),10*10(2),9*9(1)

  
  1. D Day number of menstrual cycle, d Days of continuous medication, N Number, rFSH recombinant follicle stimulating hormone (Gonal-F, merck Serono, Switzerland), rHCG recombinant human chorionic gonadotrophin (Ovidrel, merck Serono, Germany), HMG human menopausal gonadotropin (Lebaode, Livzon, Zhuhai), HCG human chorionic gonadotrophin (Livzon, Zhuhai), GnRHa (Diphereline, Ipsen, France), Ganirelix (Orgalutran, merck sharp organon, USA), Clomiphene citrate (Clomifene Citrate Tablets, Hengshan, shanghai)