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Table 5 Comparison of diagnostic performance of tests for epithelial ovarian cancers

From: Comparison of the predictive performance of risk of malignancy indexes 1–4, HE4 and risk of malignancy algorithm in the triage of adnexal masses

Test

Sensitivity%

Specificity%

Area under the curve (95% confidence interval)

RMI1

73.3

93.8

0.861 (0.731–0.992)

RMI2

73.3

89.1

0.847 (0.715–0.979)

RMI3

73.3

90.6

0.861 (0.731–0.992)

RMI4

73.3

92.2

0.868 (0.742–0.994)

ROMA

80

93

0.861 (0.731–0.992)

HE4

53.3

96.9

0.653 (0.479–0.827)

Pre-menopausal

 RMI 1

42.9%

91.5%

0.672 (0.432–0.912)

 RMI 2

42.9%

87.7%

0.653 (0.416–0.890)

 RMI 3

42.9%

87.7%

0.653 (0.416–0.890)

 RMI 4

42.9%

90.6%

0.667 (0.428–0.907)

 HE4

42.9%

98.1%

0.705 (0.459–0.950)

 ROMA

42.9%

91.5%

0.672 (0.432–0.912)

Menopausal

 RMI 1

72.2%

100%

0.861 (0.731–0.992)

 RMI 2

77.8%

91.7%

0.847 (0.715–0.979)

 RMI 3

72.2%

100%

0.861 (0.731–0.992)

 RMI 4

77.8%

95.8%

0.868 (0.742–0.994)

 HE4

77.8%

91.7%

0.653 (0.479–0.827)

 ROMA

77.2%

100%

0.861 (0.731–0.992)

  1. Data represented as percentages at 95% confidence interval
  2. PPV positive predictive value, NPV negative predictive value, RMI Risk of malignancy index, ROMA Risk Of Malignancy Algorithm, HE4 Human Epididymis Protein 4. Cut off for RMI1, RMI2, RMI3 was 200, for RMI4 was 450; for ROMA cut off for premenopausal was 11.4, for postmenopausal was 29.9; for HE4 cut off of 70 pmol/l was used