Fig. 6From: NDRG2 gene expression pattern in ovarian cancer and its specific roles in inhibiting cancer cell proliferation and suppressing cancer cell apoptosisEffects of NDRG2 on the tumorigenesis of ovarian cancer in nude mice SKOV3 cells pre-transfected with lentivirus-mediated NDRG2 overexpression or negative control were subcutaneous injected into the armpit of nude mice respectively. Lv-NDRG2 OE means SKOV3 cells were transfected with lentivirus-mediated NDRG2 overexpression vector. Lv-Vector group means SKOV3 cells were transfected with noneffective negative control lentiviral vector. a The NDRG2 mRNA expression level in Lv-NDRG2 OE group was markedly increased compared to that in Lv-Vector group. b Tumor volumes of nude mice were measured every 3 days from the 10th day after injection. Overexpression of NDRG2 significantly slowed down ovarian cancer tumor growth. c Tumors were removed from nude mice 25 days after injection. On the 25th day, tumor weight of the Lv-NDRG2 OE group was significantly lower than that of Lv-Vector group. d Picture of mice tumors illustrated that overexpression of NDRG2 significantly reduced tumor size. **P < 0.01, compared to Lv-Vector groupBack to article page