Skip to main content
Fig. 6 | Journal of Ovarian Research

Fig. 6

From: NDRG2 gene expression pattern in ovarian cancer and its specific roles in inhibiting cancer cell proliferation and suppressing cancer cell apoptosis

Fig. 6

Effects of NDRG2 on the tumorigenesis of ovarian cancer in nude mice SKOV3 cells pre-transfected with lentivirus-mediated NDRG2 overexpression or negative control were subcutaneous injected into the armpit of nude mice respectively. Lv-NDRG2 OE means SKOV3 cells were transfected with lentivirus-mediated NDRG2 overexpression vector. Lv-Vector group means SKOV3 cells were transfected with noneffective negative control lentiviral vector. a The NDRG2 mRNA expression level in Lv-NDRG2 OE group was markedly increased compared to that in Lv-Vector group. b Tumor volumes of nude mice were measured every 3 days from the 10th day after injection. Overexpression of NDRG2 significantly slowed down ovarian cancer tumor growth. c Tumors were removed from nude mice 25 days after injection. On the 25th day, tumor weight of the Lv-NDRG2 OE group was significantly lower than that of Lv-Vector group. d Picture of mice tumors illustrated that overexpression of NDRG2 significantly reduced tumor size. **P < 0.01, compared to Lv-Vector group

Back to article page