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Fig. 1 | Journal of Ovarian Research

Fig. 1

From: BRIP1, RAD51C, and RAD51D mutations are associated with high susceptibility to ovarian cancer: mutation prevalence and precise risk estimates based on a pooled analysis of ~30,000 cases

Fig. 1

The distribution of BRIP1 (a), RAD51C (b), and RAD51D (c) mutations in patients with OC. The shape and color of a mutation symbol reflect the type of mutation (see the legend), and the number of symbols reflects the identified number of particular mutations. The structures of the analyzed genes and domains in the corresponding proteins were designed based on the Ensembl genome browser and UniProt database. Horizontal lines highlight an OR of 1 (no risk – black line), an OR of 2 (the threshold for moderate risk – orange line), an OR of 4 (the threshold for high risk – blue line), and the general gene-specific OR established for a particular gene in this study (dashed red line). Gene-specific OR symbols (red x with whiskers indicating 95% CIs) are indicated on the right of each gene chart, and mutation-specific OR symbols are indicated above particular mutation positions. The c.270_271dupTA-specific OR calculated for the East Asian population is indicated in green. * or ** next to the OR symbol indicates a p-value < 0.05 and < 0.0001, respectively. Note that the association analysis was performed only for recurrent mutations (≥5 cases) also present in at least one control. The detailed values of ORs for particular mutations in the BRIP1, RAD51C, and RAD51D genes are provided in Table 2

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