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Table 1 The overall prevalence and association of BRIP1, RAD51C, and RAD51D mutations with OC risk

From: BRIP1, RAD51C, and RAD51D mutations are associated with high susceptibility to ovarian cancer: mutation prevalence and precise risk estimates based on a pooled analysis of ~30,000 cases

Gene

M/ALL OC (%)

M/ALL CTR (%)

OR; 95%CIs; p

ORadja; 95%CIs; p

BRIP1

200/22494 (0.8891)

209/115375 (0.1811)

4.94; 4.07–6.00; < 0.0001

4.32; 3.48–5.37; < 0.0001

RAD51C

149/23802 (0.6260)

130/115475 (0.1126)

5.59; 4.42–7.07; < 0.0001

5.04; 3.85–6.59; < 0.0001

RAD51D

94/22787 (0.4125)

72/120688 (0.0597)

6.94; 5.10–9.44; < 0.0001

7.60; 5.29–10.93; < 0.0001

  1. ALL total number of cases tested; CTR Controls; M Number of cases with mutation; OC Ovarian cancer cases; a, OR Adjusted for the major populations (i.e., Caucasian/European and East Asian)
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