Validation of Androgen Receptor loss as a risk factor for the development of brain metastases from ovarian cancers

Mittica, Gloria; Goia, Margherita; Gambino, Angela; Scotto, Giulia; Fonte, Mattia; Senetta, Rebecca; Aglietta, Massimo; Borella, Fulvio; Sapino, Anna; Katsaros, Dionyssios; Maggiorotto, Furio; Ghisoni, Eleonora; Giannone, Gaia; Tuninetti, Valentina; Genta, Sofia; Eusebi, Chiara; Momi, Marina; Cassoni, Paola; Valabrega, Giorgio

doi:10.1186/s13048-020-00655-2

Table 2 Clinical parameters of the 40 CNS metastases included in the study

From: Validation of Androgen Receptor loss as a risk factor for the development of brain metastases from ovarian cancers

Cases	Age	Neurological symptoms	N° of lesions	Site of lesions	Treatment of CNS metastases	bPFS (months)	bOS (months)
Previously Published Cohort
1	49	NA	Single	Parietal	Surgery, CT	11	6
2	57	Drowsiness	Single	Occipital	Surgery	68	42
3	70	Ataxia	Single	Parietal, occipital	Surgery, WBRT	29	41
4	70	Unilateral symptoms	Single	Parietal	Surgery, CT, WBRT	22	6
5	50	Headache, vertigo	Double	Parietal, occipital, frontal	Surgery, CT, WBRT	18	29
6	70	Aphasia, disorientation, dizziness	Single	Parietal	Surgery, SRS	28	56
7	52	NA	Single	Frontal	Surgery, CT, WBRT	54	7
8	62	Headache, altered walking gait	Multiple	Temporal, frontal, occipital	Surgery, WBRT	15	3
9	46	NA	Single	NA	Surgery	23	3
10	72	Ataxia, dysmetria	Multiple	Frontal (major)	Surgery, WBRT	18	7
11	74	Vertigo	Single	Frontal	Surgery, WBRT	25	64
Validation Cohort
12	56	Seizures, aphasia, altered walking gait	Single	Frontal	Surgery, WBRT	0	48
13	77	Persistent vomiting	Single	Cerebellar	Surgery	26	40
14	79	Dysarthria, altered walking gait	Single	Parietal	Surgery	36	6
15	66	Paresthesia, dizziness	Multiple	Parietal, occipital	Surgery, CT, SRS	30	34
16	69	Seizures, dysmetria	Single	Frontal	Surgery	0	12
17	67	Headache, diplopia	Single	Occipital	Surgery, CT	45	12
18	67	Headache, vomit	Single	Frontal	Surgery, WBRT	22	40
19	68	Headache	Single	Frontal	Surgery, WBRT	26	27
20	56	Aphasia, seizures, dysarthria, dysmetria	Multiple	Temporal, parietal, occipital	Surgery, CT, WBRT	61	112
21	57	Headache, vomit	Single	Cerebellar	Surgery, WBRT	18	41
22	60	Altered walking gait	Multiple	Cerebellar, supratentorial	Surgery, CT, WBRT	19	13
23	54	Headache, paresthesia, hemiparesis	Multiple	Temporal, parietal	Surgery, CT, WBRT	15	44
24	46	Altered walking gait	Single	Cerebellar	Surgery, WBRT	25	8
25	69	Altered walking gait, dizziness, Hemianopia	Multiple	Parietal, occipital	Surgery, WBRT	22	39
26	71	Headache	Double	Frontal, Cerebellar	WBRT, CT	32	27
27	51	Aphasia, verbal amnesia	Multiple	Frontal, temporal, occipital	WBRT	34	6
28	59	Headache, altered walking gait	Multiple	Cerebellar, supratentorial	WBRT	25	18
29	74	Altered walking gait, diplopia	Multiple	Cerebellar, parietal, temporal	WBRT	87	17
30	58	Seizures	Multiple	Cerebellar, supratentorial	WBRT	16	22
31	78	NA	Multiple	supratentorial	WBRT	27	2
32	60	NA	Double	Temporal, frontal	WBRT, CT	36	44
33	75	Asthenia, fatigue	Multiple	Cerebellar, supratentorial	WBRT, CT	21	3
34	51	Headache	Multiple	Parietal, occipital	WBRT, CT	72	8
35	54	NA	Single	Occipital	WBRT	1	3
36	49	Hemiparesis	Multiple	Frontal, temporal, occipital	SRS	28	51
37	39	Paresthesia, Dysarthria	Multiple	Occipital, cerebellar	WBRT, CT	4	4
38	55	Drowsiness	Multiple	Parietal, frontal	/	38	2
39	57	Headache, Paresthesia	Multiple	Frontal, parietal, occipital	WBRT, CT	1	15
40	55	Headache	Multiple	Frontal, cerebellar	WBRT, CT	11	9

NA not available, WBRT Whole Brain RadioTherapy, SRS Stereotactic RadioSurgery, CT Chemotherapy, bPFS Progression Brain Metastasis Free Survival, bOS brain metastases Overall Survival

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