Table 5 Clinico-pathological features of primary ovarian lesion of combined dataset: case dataset vs control dataset
Clinico-histopathological features | Case Dataset n = 40 (%) | Control Dataset n = 40 (%) | pValue |
|---|---|---|---|
Age, median (years) [range] | 57 [39–76] | 63.5 [36–78] | 0.960 |
Histological type | |||
 Serous | 34 (85) | 40 (100) | 0.262 |
 Clear cell | 2 (5) |  | |
 Endometrioid | 1 (2.5) |  | |
 Mucinous | 1 (2.5) |  | |
 Squamous | 1 (2.5) |  | |
 Undifferentiated | 1 (2.5) |  | |
Histological grade | |||
 G3 | 40 (100) | 40 (100) | 1 |
FIGO stage | |||
 II | 4 (10) | 4 (10) | 1 |
 III | 25 (62.5) | 25 (62.5) | |
 IV | 11 (27.5) | 11 (27.5) | |
Type of surgery | |||
 Upfront | 31 (77.5) | 18 (45) | 0.003 |
 Neoadjuvant CT + IDS | 9 (22.5) | 22 (55) | |
Macroscopic residual tumor | |||
 Present | 17 (42.5) | 19 (47.5) | 0.611 |
 Absent | 14 (35) | 20 (50) | |
 Not available | 9 (22.5) | 1 (2.5) | |
First-line chemotherapy | |||
 Platinum-based | 40 (100) | 40 (100) | 1 |
Relapse | |||
 Present | 40 (100) | 30 (75) | 0.001 |
 Absent |  | 10 (25) | |
First site of relapse | |||
 CNS | 21 (52.5) |  | < 0.001 |
 Lymph nodes and / or peritoneum | 14 (35) | 28 (93.3)a | |
 Other | 5 (12.5) | 2 (6.7)a | |
Patient’s status | |||
 Alive | 10 (25) | 21 (52.5) | 0.015 |
 Dead | 29 (72.5) | 19 (47.5) | |
 Not available | 1 (2.5) |  | |
PFS, median (months) [range] | 18 [0–62] | 17.5 [5–73] |  |
OS, median (months) [range] | 47.5 [4–173] | 40 [6–101] |  |