Fig. 1

The role of individual lncRNAs in normal granulosa cells (GCs). lncRNA-LET repressed proliferation, migration, epithelial–mesenchymal transition (EMT) and promoted apoptosis in a human GCs line KGN by activating TIMP2 and inducing the Wnt/β-catenin/Notch pathways; lncRNA-Amhr2 activated the transcription of its neighboring gene Amhr2 in primary mural and cumulus GCs and in a mouse GC line OV3121 cells; lncRNA-lncPrepþ96kb induced POP in primary ovarian mural and cumulus GCs; AK124742-PSMD6 is a potential lncRNA-mRNA biomarker in cumulus GCs for embryo selection; HAS2-AS1 caused activation of HAS2 and induced cumulus GCs migration