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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: Long non-coding RNAs in ovarian granulosa cells

Fig. 2

lncRNAs in GCs obtained from polycystic ovary syndrome (PCOS) patients. SRA is a potential risk factor for PCOS as it affects several functions of mural and cumulus GCs, including proliferation, apoptosis, inflammation, and production of angiogenic factors and hormones; PWNR2 is involved in oocyte nuclear maturation in PCOS by functioning as a ceRNA in cumulus GCs; BANCR participates in PCOS progression by promoting cumulus GCs apoptosis; LINC-01572:28 suppresses PCOS cumulus GCs proliferation and cell cycle progression via competitive binding to SKP2; TUG1 inhibits apoptosis and autophagy in PCOS GCs through inhibition of ERK/MAPK pathway; HUPCOS mediates androgen excess in follicular fluid of PCOS patients via interaction with RBPMS; CHBRP involves in steroid genesis and metabolism in PCOS GCs by interacting with transcription factors YY1 and SIX5; HCG26 knockdown in GCs inhibits cell proliferation induces estradiol production. PVT1 down-regulation and miR-17-5p up-regulation lead to PTEN inhibition, which promoting proliferation and repressing apoptosis of PCOS GCs

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