Table 2 Studies concerned with the roles of probiotics in preventing or reducing the adverse effects of cervical cancer therapies on gastrointestinal tract
From: Anti-tumor activities of probiotics in cervical cancer
Type of probiotics | Dosage | Duration of probiotic consumption | Results | References |
|---|---|---|---|---|
L. acidophilus LA-5 plus Bifidobacterium animalissubsp. Lactis BB-12 | One capsule containing 1.75 billion lyophilized live bacteria t.i.d. | From the first day until the end of radiotherapy | Severity and incidence of radiotherapy-induced diarrhea were reduced | [99] |
L. acidophilus plus bifidobacterium bifidum | 2 × 109 units of a L. acidophilus plus bifidobacterium bifidum b.i.d. | Beginning 7 days before starting radiotherapy and continuing every day during radiotherapy | Stool consistency was improved and need for anti-diarrheal medication was reduced | [105] |
L. casei DN-114001 | 96 mL of a liquid yogurt containing approximately 108 CFU/g of L. casei DN-114001 t.i.d. | Beginning 7 days before starting radiotherapy and continuing every day during radiotherapy | Stool consistency was improved but there was no reduction in the incidence of radiotherapy-induced diarrhea | [100] |
VSL#3 | one sachet containing 450 billion/g of bacteria, including four strains of lactobacilli, three strains of bifidobacteria, and one strain of Streptococcus salivarius t.i.d. | From the first day of radiation therapy until the end of the scheduled cycles of radiotherapy | Daily bowel movements and incidence of radiotherapy-induced diarrhea were reduced | [101] |
Sybmbotic | symbiotic containing 1 × 107 (CFU)/g biogel of L. acidophilus NCFM, Bifidobacterium lactis Bi-07 1 × 106 CFU/g biogel, and blue agave inulin t.i.d. | Seven weeks | Fecal calprotectin and frequency and intensity of vomiting were reduced | [104] |