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Table 2 Studies concerned with the roles of probiotics in preventing or reducing the adverse effects of cervical cancer therapies on gastrointestinal tract

From: Anti-tumor activities of probiotics in cervical cancer

Type of probiotics Dosage Duration of probiotic consumption Results References
L. acidophilus LA-5 plus Bifidobacterium animalissubsp. Lactis BB-12 One capsule containing 1.75 billion lyophilized live bacteria t.i.d. From the first day until the end of radiotherapy Severity and incidence of radiotherapy-induced diarrhea were reduced [99]
L. acidophilus plus bifidobacterium bifidum 2 × 109 units of a L. acidophilus plus bifidobacterium bifidum b.i.d. Beginning 7 days before starting radiotherapy and continuing every day during radiotherapy Stool consistency was improved and need for anti-diarrheal medication was reduced [105]
L. casei DN-114001 96 mL of a liquid yogurt containing approximately 108 CFU/g of L. casei DN-114001
t.i.d.
Beginning 7 days before starting radiotherapy and continuing every day during radiotherapy Stool consistency was improved but there was no reduction in the incidence of radiotherapy-induced diarrhea [100]
VSL#3 one sachet containing 450 billion/g of bacteria, including four strains of lactobacilli, three strains of bifidobacteria, and one strain of Streptococcus salivarius t.i.d. From the first day of radiation therapy until the end of the scheduled cycles of radiotherapy Daily bowel movements and incidence of radiotherapy-induced diarrhea were reduced [101]
Sybmbotic symbiotic containing 1 × 107 (CFU)/g biogel of L. acidophilus NCFM, Bifidobacterium lactis Bi-07 1 × 106 CFU/g biogel, and blue agave inulin t.i.d. Seven weeks Fecal calprotectin and frequency and intensity of vomiting were reduced [104]
  1. Colony-forming unit, CFU; b.i.d., twice a day; t.i.d., three times a day