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Table 2 Clinical study of stem cell therapy on POF

From: Recent trends in stem cell therapy for premature ovarian insufficiency and its therapeutic potential: a review

StatusPhaseStem cell typeSponsorClinical Trial Number
Completed1,2OCT4 marker measuredAl-Azhar UniversityNCT02151890
hUCMSC and hCBMNC transplantationShenzhen Beike Bio-Technology Co., LtdNCT01742533
autologous MSCs injectionEl-Rayadh Fertility CentreNCT02043743
autologous MSCs treatment + OCT4 marker measuredSayed BakryNCT02062931
RecruitingBMSC treatment directly to ovaryUniversity of Illinois at ChicagoNCT02696889
1embryonic stem cell derived MSC-like cell transplantation directly into bilateral ovariesChinese Academy of SciencesNCT03877471
1,2VSELs from the patient’s peripheral bloodinjected in bilateral oviducts + hormone and menstrual conditions measuredFuda Cancer Hospital, GuangzhouNCT03985462
Derivation of hESC linesHadassah Medical OrganizationNCT00353197
Active2hUCMSC treatmentSclnow Biotechnology Co., Ltd.NCT03816852
1,2intraovarian transplantation of autologous BMSCs & MSCs.Stem Cells ArabiaNCT03069209
  1. hUCMSC human umbilical cord mesenchymal stem cell, hCBMNC human cord blood-mononuclear cells, BMSC bone marrow derived mesenchymal stem cells, VSEL very small embryonic-like stem cell, hESC human embryonic stem cell