Fig. 6

THOR promotes IL-6 activation in OC cells. a The protein expression of IL-6 in shTHOR OC cells and their control cells was determined by Western bolt assay. b shTHOR OC cells and their control cells were treated with tocilizumab (20 μg/mL) or DMSO, respectively, and then subjected to western blot assay. c The proliferation of shTHOR OC cells and their control cells in the presence of tocilizumab (20 μg/mL) or DMSO, respectively, was measured using the CCK8 assay. d Invasion assay was performed using shTHOR OC cells and their control cells with or without tocilizumab (20 μg/mL) treatment. e shTHOR OC cells and their control cells were treated with tocilizumab (20 μg/mL) or DMSO, respectively, and then subjected to spheroids formation assay. f Schematic diagram of the THOR/IL-6/STAT3 regulatory pathway in OC cell lines