Fig. 6
From: Cul4B promotes the progression of ovarian cancer by upregulating the expression of CDK2 and CyclinD1
Cul4B regulated the expression of CDK2/CyclinD1 by repressing mir-372 and upregulating the 3′ UTR luciferase reporter activity of CDK2 and CyclinD1. a targetScan results showed that both 3′ UTR of CyclinD1 and CDK2 contains binding region for miR-372. b qPCR results revealed that Cul4B overexpression in ovarian cancer cells downregulates the expression of miR-372. c Luciferase reporter assay revealed that Cul4B overexpression in ovarian cancer cells upregulates the 3′ UTR luciferase reporter activity of both CDK2 and Cyclin D1