Platelet count as a biomarker for monitoring treatment response and disease recurrence in recurrent epithelial ovarian cancer

Table 3 Univariate and multivariate analysis of prognostic factors in overall survival

	Univariate analysis				Multivariate analysis
Variable	HR	95.0% CI		P value	HR	95.0% CI		P value
Age (y) ≤55 vs. > 55	1.606	0.844	−3.058	0.149	–	–	–	–
Postoperativeresidual disease Microscopic vs. Macroscopic	5.811	3.019	−11.182	P < 0.001	4.300	2.124	−8.703	P < 0.001
Grade Low vs. High	2.695	1.225	−5.928	0.014	1.714	0.733	−4.004	0.214
Stage I or II vs. III or IV	2.972	1.195	−7.393	0.019	1.799	0.656	−4.930	0.254
Plateletcount (1000/μl) ≤300 vs. > 300	2.298	1.208	−4.373	0.011	2.363	1.202	−4.645	0.013
Platelet count reduction > 25% vs. ≤25%	2.222	1.200	−4.113	0.011	2.363	1.262	−4.423	0.007
Plasmafibrinogen(g/l) 2–4 vs. > 4	1.092	0.573	−2.083	0.789	–	–	–	–
Plasma D-dimer (mg/l) ≤0.3 vs. > 0.3	0.712	0.315	−1.608	0.413	–	–	–	–

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