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Table 1 Patient characteristics in relation to preoperative blood parameters and SIR marks

From: Serum D-dimer, albumin and systemic inflammatory response markers in ovarian clear cell carcinoma and their prognostic implications

Characteristic

Na (%)

CA125b (U/ml)

Albumin b (g/l)

Leukocyte differential counts b (k/μl)

Platelet b (k/μl)

D-dimer b (mg/l)

Ratio b

Lymphocyte

Monocyte

Neutrophil

NLR

MLR

PLR

All cases

84

187.9 (6.5–5000*)

40.7 (25.9–52.1)

1.5 (0.4–2.9)

0.4 (0.03–1.6)

4.1 (1.9–15.2)

299 (124–608)

1.66 (0.19–55.20)

2.7 (1.1–20.3)

0.28 (0.03–2.00)

193.9 (77.5–955.0)

Age (years)

  ≤ 52

42 (50)

188.0 (6.5–2854)

40.7 (33.1–49.4)

1.5 (0.6–2.9)

0.4 (0.2–1.0)

4.0 (1.9–12.2)

301 (124–500)

1.66 (0.19–55.20)

2.6 (1.1–20.3)

0.25 (0.12–0.83)

201.7 (77.5–615.0)

  > 52

42 (50)

165.0 (11.1–5000*)

40.4 (25.9–52.1)

1.5 (0.4–2.4)

0.4 (0.03–1.6)

4.4 (1.9–15.2)

296 (147–608)

1.66 (0.20–20.00)

2.8 (1.1–20.3)

0.32 (0.03–2.00)

191.0 (92.1–955.0)

P value

 

0.589

0.056

0.874

0.039

0.826

0.871

0.756

0.826

0.053

0.940

FIGO stage

 IC-II

47 (56.0)

70.5 (6.5–1930.0)

43.6 (29.6–52.1)

1.5 (0.9–2.9)

0.4 (0.03–1.0)

3.6 (1.9–10.7)

292 (124–500)

1.49 (0.19–55.20)

2.2 (1.1–7.1)

0.21 (0.03–0.67)

167.5 (77.5–500.0)

 III-IV

37 (44.0)

276.9 (45.6–5000*)

39.2 (25.9–49.2)

1.4 (0.4–2.4)

0.4 (0.3–1.6)

4.6 (1.9–15.2)

311 (147–608)

2.61 (0.69–11.03)

3.2 (1.1–20.3)

0.33 (0.18–2.00)

230.0 (101.7–955.0)

P value

 

< 0.001

< 0.001

0.031

0.002

0.009

0.320

0.001

0.001

< 0.001

0.006

Residual tumor (cm)

 0

63 (75.0)

157.4 (6.5–5000*)

41.7 (28.3–52.1)

1.5 (0.6–2.9)

0.4 (0.03–1.6)

3.8 (1.9–15.2)

292 (124–608)

1.66 (0.19–55.20)

2.4 (1.1–7.1)

0.25 (0.03–0.70)

173.5 (77.5–500)

  ≤ 1

14 (16.7)

371.4 (45.6–1845.3)

38.4 (29.0–43.7)

1.4 (0.9–2.4)

0.5 (0.3–0.9)

4.7 (2.7–6.6)

318 (202–593)

2.53 (0.69–9.30)

3.2 (1.3–5.7)

0.35 (0.19–0.82)

219.8 (107.1–539.1)

  > 1

7 (8.3)

475.1 (151.6–1866.0)

33.2 (25.9–49.2)

0.9 (0.4–1.8)

0.6 (0.3–1.4)

8.1 (2.7–12.2)

342 (253–382)

3.29 (0.75–6.06)

8.2 (2.8–20.3)

0.67 (0.39–2.00)

383.3 (190.0–955.0)

P value

 

0.007

0.006

0.008

0.002

0.005

0.314

0.064

< 0.001

< 0.001

0.004

Platinum response

 Sensitive

58 (69.0)

124.6 (6.47–5000*)

41.7 (29.0–52.1)

1.5 (0.6–2.9)

0.4 (0.03–1.0)

3.8 (1.9–10.7)

279 (124–500)

1.66 (0.19–20.00)

2.4 (1.1–7.1)

0.25 (0.03–0.70)

176.7 (77.5–500.0)

 resistant

24 (28.6)

294.3 (38.21–1866.0)

39.2 (25.9–49.2)

1.5 (0.4–2.4)

0.5 (0.2–1.6)

4.9 (2.1–15.2)

316 (202–608)

3.82 (0.44–55.20)

3.2 (1.1–20.3)

0.35 (0.15–2.00)

214.3 (126.3–955.0)

P value

 

0.002

0.012

0.400

0.011

0.003

0.157

< 0.001

0.002

0.004

0.060

  1. Abbreviations: SIR systemic inflammatory response, NLR neutrophil to lymphocyte ratio, MLR monocyte to lymphocyte ratio, PLR platelet to lymphocyte ratio
  2. P values with statistical significance were denoted
  3. a Categorical data are shown in absolute value and proportion
  4. b Continuous variables are represented by median and range
  5. * The upper limit of CA125 detection is 5000