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Table 3 Potential oocyte maturation biomarkers

From: Transcriptomics of cumulus cells – a window into oocyte maturation in humans

Gene ID Description Previous Study Method of Detection Fold Change in this study
ADAMTS1 ADAM Metallopeptidase with Thrombospondin Type 1 Motif 1 Devjak et al. 2012 [19] RNAseq 2.27
Yerushalmi et al. 2014 [20] RNAseq
ANK2 Ankyrin 2 Devjak et al. 2012 [19] RNAseq − 3.13
ANKRD57 aka. SOWAHC, Sosondowah Ankyrin Repeat Domain Family Member C Ouandaogo et al. 2011 [21] Microarray −2.21
AOC2 Amine Oxidase, Copper Containing 2 Ouandaogo et al. 2011 [21] Microarray 3.72
AREG Amphiregulin Feuerstein et al. 2007 [22] RT-qPCR 5.4
BDNF Brain Derived Neurotrophic Factor Anderson et al. 2009 [23] RT-qPCR 2.68
BMP2 Bone Morphogenetic Protein 2 Devjak et al. 2012 [19] RNAseq 2.46
BUB1 BUB1 Mitotic Checkpoint Serine/Threonine Kinase Devjak et al. 2012 [19] RNAseq −4.28
Feuerstein et al. 2012 [24] Microarray
C10orf10 aka. DEPP1, Autophagy Regulator Devjak et al. 2012 [19] RNAseq 2.99
CCDC99 aka. SPDL1, Spindle Apparatus Coiled-Coil Protein 1 Devjak et al. 2012 [19] RNAseq − 3.46
CDH3 Cadherin 3 Devjak et al. 2012 [19] RNAseq −14.26
COX2 aka. PTGS2, Prostaglandin-Endoperoxide Synthase 2 Feuerstein et al. 2007 [22] RT-qPCR 4.00
Anderson et al. 2009 [23] RT-qPCR
Wathlet et al. 2011 [25] RT-qPCR
Yerushalmi et al. 2014 [20] RNAseq
CRHBP Corticotropin Releasing Hormone Binding Protein Devjak et al. 2012 [19] RNAseq −5.41
DHCR24 24-Dehydrocholesterol Reductase Yerushalmi et al. 2014 [20] RNAseq 2.29
DSE Dermatan Sulfate Epimerase Devjak et al. 2012 [19] RNAseq −2.36
F2RL1 F2R Like Trypsin Receptor 1 Ouandaogo et al. 2011 [21] Microarray −3.06
FSHR Follicle Stimulating Hormone Receptor Yerushalmi et al. 2014 [20] RNAseq −8.13
GABRA5 Gamma-Aminobutyric Acid Type A Receptor Alpha5 Subunit Devjak et al. 2012 [19] RNAseq − 3.93
GLRA2 Glycine Receptor Alpha 2 Devjak et al. 2012 [19] RNAseq −28.47
GPX Glutathione Peroxidase 3 Yerushalmi et al. 2014 [20] RNAseq −3.56
GREM1 Gremlin 1, DAN Family BMP Antagonist Anderson et al. 2009 [23] RT-qPCR −2.03
Yerushalmi et al. 2014 [20] RNAseq
HSD11B1 Hydroxysteroid 11-Beta Dehydrogenase 1 Devjak et al. 2012 [19] RNAseq 2.95
ID2 Inhibitor of DNA Binding 2 Ouandaogo et al. 2011 [21] Microarray 3.53
ID3 Inhibitor of DNA Binding 3 Devjak et al. 2012 [19] RNAseq − 4.9
ITGB3 Integrin Subunit Beta 3 Devjak et al. 2012 [19] RNAseq − 4.05
ITPKA Inositol-Trisphosphate 3-Kinase A Wathlet et al. 2011 [25] RT-qPCR 2.49
LHCGR Luteinizing Hormone/Choriogonadotropin Receptor Yerushalmi et al. 2014 [20] RNAseq 3.72
MAOB Monoamine Oxidase B Devjak et al. 2012 [19] RNAseq − 2.38
MGP Matrix Gla Protein Devjak et al. 2012 [19] RNAseq − 8.01
NDP Norrin Cystine Knot Growth Factor Devjak et al. 2012 [19] RNAseq − 2.4
NID2 Nidogen 2 Devjak et al. 2012 [19] RNAseq 5.46
NKAIN1 Sodium/Potassium Transporting ATPase Interacting 1 Devjak et al. 2012 [19] RNAseq 4.38
NOS2 Nitric Oxide Synthase 2 Yerushalmi et al. 2014 [20] RNAseq −2.48
PALLD Palladin, Cytoskeletal Associated Protein Devjak et al. 2012 [19] RNAseq −4.13
PTX3 Pentraxin 3 Zhang et al. 2005 [26] Microarray 3.08
Anderson et al. 2009 [23] RT-qPCR
SERPINE2 Serpin Family E Member 2 Feuerstein et al. 2012 [24] Microarray − 4.31
Yerushalmi et al. 2014 [20] RNAseq
SFRP4 Secreted Frizzled Related Protein 4 Devjak et al. 2012 [19] RNAseq − 20.39
Feuerstein et al. 2012 [24] Microarray
Yerushalmi et al. 2014 [20] RNAseq
SPOCK2 SPARC (Osteonectin), Cwcv And Kazal Like Domains Proteoglycan 2 Devjak et al. 2012 [19] RNAseq 2.88
Feuerstein et al. 2012 [24] Microarray
STAR Steroidogenic Acute Regulatory Protein Feuerstein et al. 2007 [22] RT-qPCR 2.67
Yerushalmi et al. 2014 [20] RNAseq
TLL2 Tolloid Like 2 Yerushalmi et al. 2014 [20] RNAseq −3.17
TNFSF4 TNF Superfamily Member 4 Devjak et al. 2012 [19] RNAseq −4.01
TSPAN7 Tetraspanin 7 Devjak et al. 2012 [19] RNAseq −3.3