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Table 2 Pooled effect estimates AMH and AMHR2 effect on ovarian stimulation outcomes

From: Can polymorphisms of AMH/AMHR2 affect ovarian stimulation outcomes? A systematic review and meta-analysis

Variant Genetic model Parameter study(N) sample size (N) Overall effect
MD 95% CI I2(%) P
AMH (rs10407022) Dominant (TT versus GG/GT) Gn dosage 4 1448 11.75 −38.70, 62.20 17 0.65
stimulation duration 3 907 0.07 −0.16, 0.31 37 0.53
oocytes retrieved 6 1723 −0.19 −1.29, 0.91 81 0.73
MII oocytes 2 787 1.20 0.76, 1.65 0 <0.00001
Homozygote (TT versus GG) Gn dosage 2 687 215.22 −142.04, 572.47 86 0.24
oocytes retrieved 3 792 0.25 −2.70, 3.21 93 0.87
MII oocytes 2 423 1.68 0.35, 3.01 70 0.01
Heterozygote (TT versus GT) Gn dosage 2 1052 −35.47 −74.68, 3.74 0 0.08
oocytes retrieved 3 1199 −0.27 −1.66, 1.12 88 0.71
MII oocytes 2 676 1.2 0.74, 1.66 0 <0.00001
Recessive (GG versus TT/GT) Gn dosage 2 1335 −0.42 −2.69, 1.85 90 0.72
oocytes retrieved 2 679 −0.42 −2.69, 1.85 90 0.72
MII oocytes 2 787 −1.22 −3.00, 0.55 88 0.18
AMHR2 (rs2002555) Dominant (AA versus GG/AG) Gn dosage 4 1230 −13.25 − 109.45, 82.95 63 0.79
Stimulation duration 3 907 2.81 −4.51, 10.13 100 0.45
oocytes retrieved 5 1614 0.01 −0.81, 0.83 66 0.97
MII oocytes 2 787 −0.02 − 0.52, 0.49 4 0.95
Variant Genetic model Parameter study(N) sample size (N) Overall effect
MD 95% CI I2(%) P
AMHR2 (rs2002555) Homozygote (AA versus GG) Gn dosage 2 631 − 150.35 − 319.02, 18.32 0 0.08
oocytes retrieved 3 969 0.32 −1.34, 1.99 73 0.70
MII oocytes 2 571 0.22 −1.98, 2.42 82 0.85
Heterozygote (AA versus AG) Gn dosage 2 928 52.37 −73.00, 177.75 74 0.41
oocytes retrieved 4 1587 −0.41 −1.31, 0.48 67 0.36
MII oocytes 2 756 −0.05 − 0.55, 0.45 0 0.84
Recessive (GG versus AA/AG) Gn dosage 2 958 147.15 −19.30, 313.60 0 0.08
oocytes retrieved 3 1342 −0.36 −2.24, 1.53 80 0.71
MII oocytes 2 787 −0.27 −2.27, 1.73 80 0.79
  1. MD: mean difference; CI: confidence interval; P: p value for association with significance set at < 0.05; I2 values as measure of heterogeneity are considered low (< 50%), moderate (51–74%) or high (> 75%); values in bold indicate significant associations;