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Table 2 Pooled effect estimates AMH and AMHR2 effect on ovarian stimulation outcomes

From: Can polymorphisms of AMH/AMHR2 affect ovarian stimulation outcomes? A systematic review and meta-analysis

Variant

Genetic model

Parameter

study(N)

sample size (N)

Overall effect

MD

95% CI

I2(%)

P

AMH (rs10407022)

Dominant (TT versus GG/GT)

Gn dosage

4

1448

11.75

−38.70, 62.20

17

0.65

stimulation duration

3

907

0.07

−0.16, 0.31

37

0.53

oocytes retrieved

6

1723

−0.19

−1.29, 0.91

81

0.73

MII oocytes

2

787

1.20

0.76, 1.65

0

<0.00001

Homozygote (TT versus GG)

Gn dosage

2

687

215.22

−142.04, 572.47

86

0.24

oocytes retrieved

3

792

0.25

−2.70, 3.21

93

0.87

MII oocytes

2

423

1.68

0.35, 3.01

70

0.01

Heterozygote (TT versus GT)

Gn dosage

2

1052

−35.47

−74.68, 3.74

0

0.08

oocytes retrieved

3

1199

−0.27

−1.66, 1.12

88

0.71

MII oocytes

2

676

1.2

0.74, 1.66

0

<0.00001

Recessive (GG versus TT/GT)

Gn dosage

2

1335

−0.42

−2.69, 1.85

90

0.72

oocytes retrieved

2

679

−0.42

−2.69, 1.85

90

0.72

MII oocytes

2

787

−1.22

−3.00, 0.55

88

0.18

AMHR2 (rs2002555)

Dominant (AA versus GG/AG)

Gn dosage

4

1230

−13.25

− 109.45, 82.95

63

0.79

Stimulation duration

3

907

2.81

−4.51, 10.13

100

0.45

oocytes retrieved

5

1614

0.01

−0.81, 0.83

66

0.97

MII oocytes

2

787

−0.02

− 0.52, 0.49

4

0.95

Variant

Genetic model

Parameter

study(N)

sample size (N)

Overall effect

MD

95% CI

I2(%)

P

AMHR2 (rs2002555)

Homozygote (AA versus GG)

Gn dosage

2

631

− 150.35

− 319.02, 18.32

0

0.08

oocytes retrieved

3

969

0.32

−1.34, 1.99

73

0.70

MII oocytes

2

571

0.22

−1.98, 2.42

82

0.85

Heterozygote (AA versus AG)

Gn dosage

2

928

52.37

−73.00, 177.75

74

0.41

oocytes retrieved

4

1587

−0.41

−1.31, 0.48

67

0.36

MII oocytes

2

756

−0.05

− 0.55, 0.45

0

0.84

Recessive (GG versus AA/AG)

Gn dosage

2

958

147.15

−19.30, 313.60

0

0.08

oocytes retrieved

3

1342

−0.36

−2.24, 1.53

80

0.71

MII oocytes

2

787

−0.27

−2.27, 1.73

80

0.79

  1. MD: mean difference; CI: confidence interval; P: p value for association with significance set at < 0.05; I2 values as measure of heterogeneity are considered low (< 50%), moderate (51–74%) or high (> 75%); values in bold indicate significant associations;
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Journal of Ovarian Research

ISSN: 1757-2215

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