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Table 2 Characteristics of patients with biochemical POI and controls in the different studies

From: Telomere length in granulosa cells and leukocytes: a potential marker of female fertility? A systematic review of the literature

Studies Number Criteria of patient’s inclusion Age
Butts et al. 2009 [38] 12 POF FSH ≥ 11,4 IU/L and estradiol ≤293,6 pmol/L 30–37
42 controls Normal FSH, tubal factor or male infertility 23–37
Hanna et al. 2009 [39] 34 POF Three-month amenorrhea, FSH > 40 IU/L before the age of 40 21–50
108 controls Overall population 17–55
Xu et al. 2017 [42] 120 POF Regular cycles, FSH ≥ 10 UI/L, unilateral AFC < 5 ≤ 40
279 control (leukocytes)
90 controls (granulosa)
Lack of criteria
Miranda-Furtado et al. 2018 [40] 46 POF Amenorrhea, FSH > 40 UI/L before the age of 40 18–41
75 controls Regular cycles, FSH < 10 UI/L
Sayban et al. 2018 [41] 40 POF Six-month amenorrhea, FSH > 40 UI/L before the age of 40 <  40
40 controls Regular cycle, normal FSH