Telomere length in granulosa cells and leukocytes: a potential marker of female fertility? A systematic review of the literature

Table 2 Characteristics of patients with biochemical POI and controls in the different studies

Studies	Number	Criteria of patient’s inclusion	Age
Butts et al. 2009 [38]	12 POF	FSH ≥ 11,4 IU/L and estradiol ≤293,6 pmol/L	30–37
Butts et al. 2009 [38]	42 controls	Normal FSH, tubal factor or male infertility	23–37
Hanna et al. 2009 [39]	34 POF	Three-month amenorrhea, FSH > 40 IU/L before the age of 40	21–50
Hanna et al. 2009 [39]	108 controls	Overall population	17–55
Xu et al. 2017 [42]	120 POF	Regular cycles, FSH ≥ 10 UI/L, unilateral AFC < 5	≤ 40
Xu et al. 2017 [42]	279 control (leukocytes) 90 controls (granulosa)	Lack of criteria	≤ 40
Miranda-Furtado et al. 2018 [40]	46 POF	Amenorrhea, FSH > 40 UI/L before the age of 40	18–41
Miranda-Furtado et al. 2018 [40]	75 controls	Regular cycles, FSH < 10 UI/L	18–41
Sayban et al. 2018 [41]	40 POF	Six-month amenorrhea, FSH > 40 UI/L before the age of 40	< 40
Sayban et al. 2018 [41]	40 controls	Regular cycle, normal FSH	< 40

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