Table 3 BRCA1 gene mutation positivity related upregulated and downregulated miRNAs and target molecules. An additional table file shows this in more detail [see Additional file 1].
miRNAs | Fold change (FC) values | Sequence of miRNA | miRNAStatus | Target genes |
|---|---|---|---|---|
miR-4449 | 2,56 | CGUCCCGGGGCUGCGCGAGGCA | Upregulated | ZFHX3 |
miR-4653-3p | 2,92 | UGGAGUUAAGGGUUGCUUGGAGA | Upregulated | ATG2A, CREBL2, MAT2A, FRS2, TMED4, UBN2 |
miR-486-5p | 3,34 | UCCUGUACUGAGCUGCCCCGAG | Upregulated | OLFM4,CD40,ARHGAP5, IGF1R, DOCK3, CADM1 |
miR-5739 | 2,03 | GCGGAGAGAGAAUGGGGAGC | Upregulated | DLX6,CD207,CHIC1,PPL2A, PLXDC1 |
miR-6165 | 2,24 | CAGCAGGAGGUGAGGGGAG | Upregulated | PER1,TFAP2A,FADS1, AMER1,LUZP1, COX6B1 |
miR-874-3p | 2,08 | CUGCCCUGGCCCGAGGGACCGA | Upregulated | HDAC1, AQP3, STAT3, CDK9 |
miR-126-3p | −24,03 | UCGUACCGUGAGUAAUAAUGCG | Downregulated | TOM1, CRK, VEGFA, SOX2, TWF1, PITPNC1, IGFBP2, KRAS |
miR-320a | −2,55 | AAAAGCUGGGUUGAGAGGGCGA | Downregulated | MCL1, BANP, ITGB3, BMI1, NRP1, NFATC3, TRPC5 |
miR-320b | −2,45 | AAAAGCUGGGUUGAGAGGGCAA | Downregulated | CDK6,DCTN5,SYNCRIP,ARF1, BCL9L, ZNF600 |
miR-320c | −2,26 | AAAAGCUGGGUUGAGAGGGU | Downregulated | SYNCRIP,FBXO28,SMARCC, NPM3 |
miR-320d | −2,39 | AAAAGCUGGGUUGAGAGGA | Downregulated | DCTN5, SYNCRIP, FBXO28 |
miR-320e | −2,42 | AAAGCUGGGUUGAGAAGG | Downregulated | DCTN5, NPM3, ZNF275, DDX19A, NCAPD2, TXNL1 |
miR-324-3p | −2,98 | ACUGCCCCAGGUGCUGCUGG | Downregulated | WNT9B, CREBBP, DVL2, WNT2B |
miR-3656 | −2,16 | GGCGGGUGCGGGGGUGG | Downregulated | MRPL12, LSP1, MNT, PRDM2, ZNF770, CECR1 |
miR-4284 | −2,96 | GGGCUCACAUCACCCCAU | Downregulated | BCL2L11,RBBP5,HNRNPA1, ZNF264, TRIB3, CRTAP |
miR-4428 | −6,05 | CAAGGAGACGGGAACAUGGAGC | Downregulated | MSL1,MAPRE3,MYH14,CASP2, CCND2, CDK14,TP63 |
miR − 4516 | -4,34 | GGGAGAAGGGUCGGGGC | Downregulated | STAT3,M6PR,GPR137C,CCND2, CCNT1, CDKN1A, SCOC, TP53 |
miR-4741 | −3,65 | CGGGCUGUCCGGAGGGGUCGGCU | Downregulated | DDX39B,MAPK1, ZBTB39, HMGA1, |
miR-484 | −2,97 | UCAGGCUCAGUCCCCUCCCGAU | Downregulated | FIS1, PAGR1, ZEB1, SLC11A2, SMAD2, ANAPC7, TBRG1 |
miR-564 | −2,45 | AGGCACGGUGUCAGCAGGC | Downregulated | GID4, CNBP, E2F3, RCAN3, AKT2, APPL1, SLC1A2, GPR155 |
miR − 6089 | -6,03 | GGAGGCCGGGGUGGGGCGGGGCGG | Downregulated | NKX2, TPT1, KCTD5, BBX, SGCD, CDH7, CCNB1, |
miR-6869 − 5p | -5,38 | GUGAGUAGUGGCGCGCGGCGGC | Downregulated | TUBB2A,MAPK1,NRBF2, WEE1,HMGA2, MAPK1, STAG2 |
miR-6891-5p | −2,23 | UAAGGAGGGGGAUGAGGGG | Downregulated | CHD4, CD207, DDX6, CHRDL1, CCND2, TP63 |
miR-7107-5p | −3,43 | UCGGCCUGGGGAGGAGGAAGGG | Downregulated | VAV3, CASP16, CCND1, CASP16, MAPK14, |
miR-7847 − 3p | -3,1 | CGUGGAGGACGAGGAGGAGGC | Downregulated | HAVCR1, POTED, DNAJC10, SOD2, M6PR, CDK19 |