Fig. 6

PPI network construction of the integrated DEGs and SEP selection. A. The PPI network on the left was drawn using Cytoscape, and the interaction score was set to medium confidence (0.400). The network nodes represent proteins (red: upregulated proteins and blue: down-regulated proteins), and edges represent protein-protein associations. Three clusters on the right represent the top 3 subnets. B. The gene expression heatmap of the differentially expressed DEGs in TCGA and GTEx. C. Venn plot showing the intersection of the downregulated DEGs and hub genes in the blue module. D. Violin plot showing the expression of indicated genes in TCGA and GTEx (by Kruskal-Wallis test, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)