Fig. 2

miR-1271-5p directly target TIAM1 in OC. a Venn diagram indicated that TIAM1 might be a candidate target of miR-1271-5p. Violet represents upregulated expression genes in OC; yellow represents putative target genes of miR-1271-5p. b TIAM1 was expressed at higher levels in OC samples (n = 378) compared with normal cases (n = 88) on the basis of TCGA database, P < 0.0001. c Overall survival curve of TIAM1 in OC, P = 0.02736. d The correlation between miR-1271-5p and TIAM1 was testified using luciferase reporter gene assay, ^**P < 0.01 versus miR-NC group. (E) Pearson’s correlation analysis was applied to evaluate the relationship between miR-1271-5p expression and TIAM1 expression, P < 0.0001, r = − 0.4066