Fig. 1

Association of KLK7 mRNA expression levels with KLK7 protein expression in advanced HGSOC. Relative KLK7 mRNA expression levels (normalized to the housekeeping gene HPRT1) were quantified by qPCR and protein expression levels were measured by ELISA (ng KLK7 per mg of total protein, determined in tumor tissue extracts). Higher KLK7 protein levels are present in the group with increased KLK7 mRNA levels (Mann-Whitney test; p = 0.007). The 67th percentile (tertiles 1 + 2 versus tertile 3) of the whole patient cohort (n = 139) was used as cut-off point for dichotomization of KLK7 mRNA levels into low versus high