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Table 2 Univariate Cox regression analysis of KLK mRNA expression levels in advanced high-grade serous ovarian cancer

From: Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer

Clinical parameters

PFS

OS

No.a

HR (95% CI)b

p

No.a

HR (95% CI)b

p

Age

  

0.762

  

0.414

 ≤ 60 years

43

1

 

49

1

 

 > 60 years

62

1.08 (0.67–1.72)

 

70

1.24 (0.74–2.06)

 

Residual tumor mass

  

< 0.001

  

< 0.001

 0 mm

58

1

 

60

1

 

 > 0 mm

47

2.41 (1.53–3.90)

 

57

3.80 (2.17–6.65)

 

Ascites fluid volume

  

0.019

  

0.005

 ≤ 500 ml

61

1

 

66

1

 

 > 500 ml

38

1.79 (1.10–2.90)

 

46

2.10 (1.25–3.54)

 

KLK7 mRNAc

  

0.025

  

0.055

 low

73

1

 

82

1

 

 high

32

1.75 (1.07–2.84)

 

37

1.66 (0.99–2.79)

 

KLK5 + KLK7 mRNAd

  

0.016

  

0.080

 low

52

1

 

60

1

 

 high

53

1.79 (1.11–2.86)

 

59

1.58 (0.95–2.63)

 
  1. Chi-square test, significant p-values (p ≤ 0.05) are indicated in bold, trends towards significance (p ≤ 0.08) in italics.
  2. a Number of patients
  3. b HR: hazard ratio (CI: confidence interval) of univariate Cox regression analysis
  4. c Dichotomized into low and high levels by the 67th percentile
  5. d Dichotomized into low by KLK5 low and KLK7 low, and high by KLK5 high and/or KLK7 high; cut-off point: KLK5 = 67th percentile, KLK7 = 67th percentile
  6. Due to missing values, numbers do not always add up to n = 105 (PFS) and n = 119 (OS).