|
Clinical parameters
|
PFS
|
OS
|
|---|
|
No.a
|
HR (95% CI)b
|
p
|
No.a
|
HR (95% CI)b
|
p
|
|---|
|
Age
| | |
0.762
| | |
0.414
|
|
≤ 60 years
|
43
|
1
| |
49
|
1
| |
|
> 60 years
|
62
|
1.08 (0.67–1.72)
| |
70
|
1.24 (0.74–2.06)
| |
|
Residual tumor mass
| | |
< 0.001
| | |
< 0.001
|
|
0 mm
|
58
|
1
| |
60
|
1
| |
|
> 0 mm
|
47
|
2.41 (1.53–3.90)
| |
57
|
3.80 (2.17–6.65)
| |
|
Ascites fluid volume
| | |
0.019
| | |
0.005
|
|
≤ 500 ml
|
61
|
1
| |
66
|
1
| |
|
> 500 ml
|
38
|
1.79 (1.10–2.90)
| |
46
|
2.10 (1.25–3.54)
| |
|
KLK7 mRNAc
| | |
0.025
| | |
0.055
|
|
low
|
73
|
1
| |
82
|
1
| |
|
high
|
32
|
1.75 (1.07–2.84)
| |
37
|
1.66 (0.99–2.79)
| |
|
KLK5 + KLK7 mRNAd
| | |
0.016
| | |
0.080
|
|
low
|
52
|
1
| |
60
|
1
| |
|
high
|
53
|
1.79 (1.11–2.86)
| |
59
|
1.58 (0.95–2.63)
| |
- Chi-square test, significant p-values (p ≤ 0.05) are indicated in bold, trends towards significance (p ≤ 0.08) in italics.
- a Number of patients
- b HR: hazard ratio (CI: confidence interval) of univariate Cox regression analysis
- c Dichotomized into low and high levels by the 67th percentile
- d Dichotomized into low by KLK5 low and KLK7 low, and high by KLK5 high and/or KLK7 high; cut-off point: KLK5 = 67th percentile, KLK7 = 67th percentile
- Due to missing values, numbers do not always add up to n = 105 (PFS) and n = 119 (OS).
