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Table 2 Univariate Cox regression analysis of KLK mRNA expression levels in advanced high-grade serous ovarian cancer

From: Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer

Clinical parameters PFS OS
No.a HR (95% CI)b p No.a HR (95% CI)b p
Age    0.762    0.414
≤ 60 years 43 1   49 1  
> 60 years 62 1.08 (0.67–1.72)   70 1.24 (0.74–2.06)  
Residual tumor mass    < 0.001    < 0.001
0 mm 58 1   60 1  
> 0 mm 47 2.41 (1.53–3.90)   57 3.80 (2.17–6.65)  
Ascites fluid volume    0.019    0.005
≤ 500 ml 61 1   66 1  
> 500 ml 38 1.79 (1.10–2.90)   46 2.10 (1.25–3.54)  
KLK7 mRNAc    0.025    0.055
low 73 1   82 1  
high 32 1.75 (1.07–2.84)   37 1.66 (0.99–2.79)  
KLK5 + KLK7 mRNAd    0.016    0.080
low 52 1   60 1  
high 53 1.79 (1.11–2.86)   59 1.58 (0.95–2.63)  
  1. Chi-square test, significant p-values (p ≤ 0.05) are indicated in bold, trends towards significance (p ≤ 0.08) in italics.
  2. a Number of patients
  3. b HR: hazard ratio (CI: confidence interval) of univariate Cox regression analysis
  4. c Dichotomized into low and high levels by the 67th percentile
  5. d Dichotomized into low by KLK5 low and KLK7 low, and high by KLK5 high and/or KLK7 high; cut-off point: KLK5 = 67th percentile, KLK7 = 67th percentile
  6. Due to missing values, numbers do not always add up to n = 105 (PFS) and n = 119 (OS).