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Table 3 Multivariate Cox regression analysis of KLK mRNA expression levels in advanced high-grade serous ovarian cancer

From: Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer

Clinical parameters PFS OS
No.a HR (95% CI)b p No.a HR (95% CI)b p
Age    0.592    0.660
≤ 60 years 41 1   46 1  
> 60 years 57 0.87 (0.53–1.44)   63 1.13 (0.65–1.96)  
Residual tumor mass    0.005    < 0.001
0 mm 57 1   59 1  
> 0 mm 41 2.20 (1.27–3.81)   50 3.29 (1.69–6.41)  
Ascites fluid volume    0.363    0.605
≤ 500 ml 60 1   64 1  
> 500 ml 38 1.33 (0.76–2.31)   45 1.18 (0.63–2.20)  
KLK7 mRNAc    0.010    0.041
low 72 1   80 1  
high 26 2.14 (1.20–3.82)   29 1.89 (1.03–3.49)  
KLK5 + KLK7 mRNAd    0.067    0.313
low 51 1   59 1  
high 47 1.59 (0.97–2.61)   50 1.33 (0.76–2.31)  
  1. Chi-square test, significant p-values (p ≤ 0.05) are indicated in bold, trends towards significance (p ≤ 0.08) in italics.
  2. aNumber of patients
  3. bHR hazard ratio (CI confidence interval) of multivariate Cox regression analysis
  4. cDichotomized into low and high levels by the 67th percentile
  5. dDichotomized into low level by KLK5 low and KLK7 low, and high level by KLK5 high and/or KLK7 high; cut-off point: KLK5 = 67th percentile, KLK7 = 67th percentile