Table 3 Multivariate Cox analysis of the training cohort based on the results of lasso regression
OS | CSS | |||
|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Age, years | ||||
< 50 | Reference | Reference | ||
50–60 | 0.694 (0.494–0.974) | 0.035 | 0.714 (0.501–1.018) | 0.063 |
> 60 | 0.781 (0.556–1.098) | 0.155 | 0.735 (0.511–1.057) | 0.097 |
Laterality | ||||
Unilateral | Reference | Reference | ||
Bilateral | 1.789 (1.283–2.496) | < 0.001 | 1.792 (1.265–2.538) | 0.001 |
AJCC Stage (7th) | ||||
I | Reference | Reference | ||
II | 3.039 (1.806–5.116) | < 0.001 | 3.035 (1.725–5.341) | < 0.001 |
III | 8.683 (6.015–12.536) | < 0.001 | 9.168 (6.204–13.549) | < 0.001 |
IV | 7.466 (4.318–12.909) | < 0.001 | 7.862 (4.392–14.073) | < 0.001 |
LN dissected, n | ||||
No | Reference | Reference | ||
1–10 | 0.738 (0.517–1.054) | 0.094 | 0.765 (0.524–1.118) | 0.167 |
> 10 | 0.565 (0.403–0.794) | < 0.001 | 0.597 (0.416–0.856) | 0.005 |
LN | ||||
No dissection or Negative | Reference | Reference | ||
Positive | 1.341 (0.884–2.035) | 0.168 | 1.247 (0.794–1.958) | 0.337 |
Organ Metastasis | ||||
No | Reference | Reference | ||
Yes | 2.326 (1.203–4.497) | 0.012 | 2.256 (1.123–4.535) | 0.022 |
Radiotherapy | ||||
No/Unknown | Reference | Reference | ||
Yes | 1.598 (0.776–3.287) | 0.203 | 1.526 (0.705–3.301) | 0.283 |
Chemotherapy | ||||
No/Unknown | Reference | Reference | ||
Yes | 0.531 (0.362–0.780) | 0.001 | 0.615 (0.401–0.944) | 0.026 |