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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: LncRNA HOTAIRM1, miR-433-5p and PIK3CD function as a ceRNA network to exacerbate the development of PCOS

Fig. 2

PIK3CD and miR-433-5p were selected as the downstream molecules related to HOTAIRM1. a GSEA enrichment analysis revealed that apoptotic pathway was closely related to PCOS. b 9 genes including HOTAIRM1 were obtained from the intersection of apoptosis-related genes and differentially expressed genes in PCOS. c Data from GSE34526 showed that PIK3CD was highly expressed in PCOS samples, p < 0.05. d A positive association between HOTAIRM1 and PIK3CD expression was identified, p = 0.0433. eThe miRNAs corresponding to PIK3CD or HOTAIRM1 were predicted by Targetscan or LncBase, respectively. Intersecting 31 common miRNAs with differentially expressed miRNAs in PCOS to obtain miR-433-5p. f Data from GSE86241 displayed that miR-433-5p was under expressed in PCOS patients, p < 0.05

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Journal of Ovarian Research

ISSN: 1757-2215

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