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Fig. 4 | Journal of Ovarian Research

Fig. 4

From: LncRNA HOTAIRM1, miR-433-5p and PIK3CD function as a ceRNA network to exacerbate the development of PCOS

Fig. 4

HOTAIRM1 inhibited the growth and promoted the apoptosis of KGN cells by modulation of miR-433-5p and PIK3CD. a Data from CCK-8 assay showed that the inhibitory effect of HOTAIRM1 on KGN cells growth was suppressed by miR-433-5p mimic or PIK3CD depletion. b Analysis from CCK-8 revealed that depletion of miR-433-5p suppressed the promoting effect of si-HOTAIRM1 on KGN cells viability, upregulation of PIK3CD has a similar result. c Flow cytometry assay displayed that the promoting effect of HOTAIRM1 on KGN cells apoptosis was inhibited by miR-433-5p mimic or PIK3CD depletion. d Analysis from flow cytometry showed that knockdown of miR-433-5p attenuated the inhibitory effect of si-HOTAIRM1 on KGN cells apoptosis, while the inhibitory effect of si-HOTAIRM1 on KGN cells apoptosis was suppressed by PIK3CD upregulation. **p < 0.01 vs. control, ##p < 0.01 vs. HOTAIRM1 or si-HOTAIRM1, &p < 0.05, &&p < 0.01 vs. mimic or inhibitor

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Journal of Ovarian Research

ISSN: 1757-2215

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