Fig. 5

Inhibition of miR-216b-5p could rescue the effect of lnc-SNHG1 inhibition on the sensitivity of A2780/Taxol cells to paclitaxel. a qRT-PCR analysis of miR-216b-5p expression in A2780/Taxol cell lines after transfecion. b-e Biological functions of A2780/Taxol cells co-transfected with si-SNHG1 and miR-216b-5p inhibitor (si-SNHG1 + miR inhibitor NC group; WT used as the control group) were measured. b The CCK-8 test results showed that A2780/Taxol cells co-transfected with si-SNHG1 and miR-216b-5p inhibitor had significantly higher cell proliferation compared with the si-SNHG1 + miR inhibitor NC group. c-e Co-transfection with si-SNHG1 and miR-216b-5p inhibitor remarkably led to a decrease in apoptosis, but increased cell migration and number of colonies of A2780/Taxol cells. ^***P < 0.001