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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: Berberine inhibited metastasis through miR-145/MMP16 axis in vitro

Fig. 2

Berberine inhibits proliferation, migration and invasion through miR-145 in SKOV3 and 3AO cells. a qRT-PCR results showed berberine promoted miR-145 expression, and this promotion effect was offset by transfection of miR-145 inhibitor. b CCK8 assay results showed berberine inhibited proliferation of SKOV3 and 3AO cells, and this inhibition was blocked by downexpression of miR-145. Wound healing assay showed berberine inhibited migration of SKOV3 and 3AO cells, and this inhibition was blocked by downexpression of miR-145. d Transwell assay showed berberine inhibited invasion of SKOV3 and 3AO cells, and this inhibition was blocked by downexpression of miR-145(200×). e qRT-PCR results showed berberine inhibited the expression of MMP16, and the inhibition of MMP16 was counteracted by downexpression of miR-145. Western blot assay showed berberine inhibited the expression of MMP16, and the inhibition of MMP16 was counteracted by downexpression of miR-145. P < 0.05, **P < 0.01, t-test

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