Fig. 4

miR-145 inhibits proliferation, migration and invasion of SKOV3 and 3AO cells by targeting MMP16. a qRT-PCR results showed overexpression of miR-145 inhibited MMP16 expression, and MMP16 expression was increased by transfection MMP16 plasmid. b Western blot results showed overexpression of miR-145 inhibited MMP16 expression, and MMP16 expression was increased by transfection MMP16 plasmid. c CCK8 assay results showed miR-145 inhibited proliferation, and the inhibition effect was reversed by MMP16 overexpression. d Wound healing assay showed miR-145 inhibited migration, and the inhibition effect was reversed by MMP16 overexpression. e Transwell assay showed miR-145 inhibited invasion, and the inhibition effect was reversed by MMP16 overexpression(200×). P < 0.05, **P < 0.01, t-test