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Table 3 COS, IVF outcomes and biochemical markers in FF

From: Age-related decline in the expression of GDF9 and BMP15 genes in follicle fluid and granulosa cells derived from poor ovarian responders

 

group A (n = 63)

Group B (n = 65)

Group C (n = 68)

COS

 Dosage of rFSH (IU)

2476.31 ± 379.34

2556.69 ± 419.57

2586.90 ± 587.63

 Duration of COS (d)

9.89 ± 2.85

9.68 ± 2.22

9.33 ± 2.34

 E2 on trigger day (pg/mL)

756.95 ± 191.65

740.23 ± 180.47

721.03 ± 151.62

 Endometrial thickness (mm)

9.10 ± 1.89

8.95 ± 1.91

8.81 ± 1.61

 Number of oocytes retrieved

2.98 ± 0.67

2.82 ± 0.87

2.68 ± 0.90

 Number of MII

2.54 ± 0.94

2.43 ± 0.79

2.37 ± 0.74

 Number of 2PN ab

2.08 ± 0.93

1.87 ± 0.87

1.36 ± 0.58

 Number of transplantable embryos ab

2.02 ± 0.57

1.85 ± 0.71

1.22 ± 0.49

 Cancel cycle rate (%)

11.11% (7/63)

12.31% (8/65)

23.53% (16/68)

ET

 Number of embryos per ET

1.43 ± 0.50

1.44 ± 0.50

1.33 ± 0.47

 Implantation rate (%) ab

30.00% (24/80)

24.39% (20/82)

10.14% (7/69)

 Clinical pregnancy rate (%) ab

37.50% (21/56)

29.82% (17/57)

11.54% (6/52)

 Miscarriage rate (%)

9.52% (2/21)

23.53% (4/17)

33.33% (2/6)

 Multiple pregnancy rate (%)

14.29% (3/21)

17.65% (3/17)

16.67% (1/6)

In FF

 GDF9 (pg/ml) abc

1020 ± 117

904 ± 70

671 ± 53

 BMP15 (pg/ml) abc

666 ± 40

643 ± 46

420 ± 40

  1. Data are presented as mean ± SD or percentage (number). Abbreviations: COS Controlled ovarian stimulation, E2 Estradiol, ET Embryos transferred, FF Follicle fluid, GDF9 Growth differentiation factor 9, BMP15 Bone morphogenetic protein-15. Chi-squared test was used to compare the rates of maturation, fertilization, cleaved embryo, higher quality embryo, cancel cycle, implantation, clinical pregnancy, miscarriage and multiple pregnancy between the two groups. P < 0.05 was considered as statistically significant
  2. a P < 0.05, group A vs. group C
  3. b P < 0.05, group B vs. group C
  4. c P < 0.05, group A vs. group B