Table 3 Classification base on the two-year PFS and the AUC value using the clearance of HE4 and CA125
Two-year PFS | Sensitivity | Specificity | PPV | NPV | Accuracy | P-value | AUC | ||
|---|---|---|---|---|---|---|---|---|---|
Yes | No | ||||||||
HE4 clearance | HE4 non-clearance | ||||||||
1 cycle | 45/59 (76.3%) | 14/30 (46.7%) | 46.7% | 76.3% | 50.0% | 73.8% | 66.3% | 0.078 | 0.615 |
3 cycle | 50/59 (84.7%) | 17/30 (56.7%) | 56.7% | 84.7% | 65.4% | 79.4% | 75.3% | 0.001 | 0.707 |
6 cycle | 51/59 (86.4%) | 14/30 (46.7%) | 46.7% | 86.4% | 63.6% | 76.1% | 73.0% | 0.011 | 0.666 |
CA125 clearance | CA125 non-clearance | ||||||||
1 cycle | 43/59 (72.9%) | 17/30 (56.7%) | 56.7% | 72.9% | 51.5% | 76.8% | 67.4% | 0.023 | 0.648 |
3 cycle | 56/59 (94.9%) | 7/30 (23.3%) | 23.3% | 94.9% | 70.0% | 70.9% | 70.8% | 0.161 | 0.591 |
6 cycle | 57/59 (96.6%) | 7/30 (23.3%) | 23.3% | 96.9% | 77.8% | 71.3% | 71.9% | 0.126 | 0.600 |
HE4 or CA125 clearance | Both HE4 and CA125 non-clearance | ||||||||
3 cycle of HE4 or 1 cycle of CA125 | 37/59 (62.7%) | 25/30 (83.3%) | 83.3% | 62.7% | 53.2% | 88.1% | 69.7% | 0.000 | 0.730 |
Both HE4 and CA125 clearance | HE4 or CA125 non-clearance | ||||||||
3 cycle of HE4 and 1 cycle of CA125 | 56/59 (94.9) | 9/30 (30.0%) | 30.0% | 94.9% | 75.0% | 72.7% | 73.0% | 0.056 | 0.625 |