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Table 4 Univariate and multivariate analyses for OS and PFS

From: Early clearance of serum HE4 and CA125 in predicting platinum sensitivity and prognosis in epithelial ovarian cancer

  Univariate analysis Multivariate analysis
OS PFS OS PFS
HR(95%CI) p-value HR(95%CI) p-value HR(95%CI) p-value HR(95%CI) p-value
Age 1.033 (0.988–1.080) 0.155 1.001 (0.969–1.035) 0.931     
Grade 1 vs. grade 2,3 3.566 (0.474–26.854) 0.217 1.862 (0.570–6.080) 0.303     
Stage 1.946 (1.096–3.455) 0.023 2.092 (1.385–3.161) 0.000    1.877 (1.154–3.052) 0.011
Serous vs. other histopathology 1.114 (0.452–2.745) 0.814 0.815 (0.417–1.595) 0.550     
HE4-median pretreatment 1.893 (0.744–4.815) 0.181 2.325 (1.157–4.673) 0.018    2.315 (1.084–4.941) 0.030
HE4-clearance after 3rd cycle of chemotherapy 8.295 (2.984–23.057) 0.000 3.632 (1.877–7.027) 0.000 8.294 (2.980–23.085) 0.000 2.713 (1.361–5.407) 0.005
CA125-median pretreatment 0.645 (0.259–1.606) 0.346 0.878 (0.456–1.690) 0.697     
CA125-clearance after 1st cycle of chemotherapy 2.556 (1.4027–6.361) 0.044 2.435 (1.260–4.709) 0.008 2.549 (1.019–6.378) 0.045 3.853 (1.888–7.865) 0.000