Table 4 Univariate and multivariate analyses for OS and PFS

Age

1.033 (0.988–1.080)

0.155

1.001 (0.969–1.035)

0.931

Grade 1 vs. grade 2,3

3.566 (0.474–26.854)

0.217

1.862 (0.570–6.080)

0.303

Stage

1.946 (1.096–3.455)

0.023

2.092 (1.385–3.161)

0.000

1.877 (1.154–3.052)

0.011

Serous vs. other histopathology

1.114 (0.452–2.745)

0.814

0.815 (0.417–1.595)

0.550

HE4-median pretreatment

1.893 (0.744–4.815)

0.181

2.325 (1.157–4.673)

0.018

2.315 (1.084–4.941)

0.030

HE4-clearance after 3rd cycle of chemotherapy

8.295 (2.984–23.057)

0.000

3.632 (1.877–7.027)

0.000

8.294 (2.980–23.085)

0.000

2.713 (1.361–5.407)

0.005

CA125-median pretreatment

0.645 (0.259–1.606)

0.346

0.878 (0.456–1.690)

0.697

CA125-clearance after 1st cycle of chemotherapy

2.556 (1.4027–6.361)

0.044

2.435 (1.260–4.709)

0.008

2.549 (1.019–6.378)

0.045

3.853 (1.888–7.865)

0.000