Fig. 3
From: miR-362-3p acts as a tumor suppressor by targeting SERBP1 in ovarian cancer
SERBP1 is a direct target of miR-362-3p. a Nineteen target genes that can bind to miR-362-3p were selected using three online bioinformatics prediction software programs (TargetScan, miRWalk, and miRTarBase). b Putative wild-type (WT) and mutant-type (MUT) miR-362-3p target sequences of SERBP1 mRNA 3’ UTRs. c, d SERBP1 mRNA and protein expression in ovarian cancer cell lines are upregulated compared to that in normal ovarian epithelium cell lines. e Relative luciferase activity in ovarian cancer cells cotransfected with constructs carrying wild-type or mutant SERBP1 mRNA 3’ UTRs with the miR-362-3p mimic. f-i Effects of miR-362-3p mimic and inhibitor on SERBP1 mRNA and protein expression in ovarian cancer cells, respectively. Data are shown as the means ± SDs. *P < 0.05