Fig. 5

miR-362-3p suppresses ovarian tumor growth and invasion in vivo. a qPCR analysis of miR-362-3p expression in tumor tissue from the mimic and NC groups. b qPCR analysis of SERBP1 mRNA expression in tumor tissues. c Western blot analysis of SERBP1 protein expression in tumor tissues. Each band represents a sample from six individual mice. d miR-362-3p mimics inhibited ovarian cancer growth in the xenograft mouse model. e Representative images of H&E staining of tumor sections (magnification 200×). (f) qPCR analysis of miR-362-3p expression in metastatic lung tumor tissues. g qPCR analysis of SERBP1 mRNA expression in metastatic lung tumor tissues. h Western blot analysis of SERBP1 protein expression in metastatic lung tumor tissues. Each band represents a sample from six individual mice. i The miR-362-3p mimic decreased the number of lung nodules. j Representative images of immunofluorescence staining showed that SERBP1 protein expression was downregulated in metastatic lung sections of the mimic group (magnification 400×). k. Representative images of H&E staining of metastatic lung sections (magnification 200×). N = 6/group for triplicate assays. Data are shown as the means ± SDs. *P < 0.05