Table 1 Identified differential lipid species between two ovarian cell lines derived exosomes
LipidIon | CalMz | RT (min) | Fold Change | P-value | OPLS-DA VIP | QCRSD |
|---|---|---|---|---|---|---|
LPC(16:0) + H | 496.33977 | 3.3190213 | 3.2401429 | 0.0003273 | 1.1373 | 0.0297514 |
LPC(18:0) + H | 524.37107 | 4.7209243 | 18.269889 | 0.0003722 | 2.60482 | 0.0162352 |
ChE(18:2) + NH4 | 666.61836 | 22.834863 | 72.791038 | 0.0003399 | 2.89397 | 0.011065 |
CerG1(d18:1/16:0) + H | 700.5722 | 11.699674 | 3.2940782 | 0.0306673 | 1.14636 | 0.0045913 |
SM(d34:2) + H | 701.5592 | 10.295418 | 0.4433831 | 0.0076993 | 1.16119 | 0.0658362 |
SM(d34:1) + H | 703.57485 | 11.59398 | 0.5114373 | 0.0367638 | 1.5197 | 0.0020378 |
LPG(32:0) + H | 709.5378 | 12.101539 | 42.668799 | 0.0141787 | 2.26234 | 0.0588612 |
PC(32:1e) + H | 718.57452 | 12.887364 | 0.1043478 | 0.0001296 | 2.05444 | 0.0049736 |
PC(31:0) + H | 720.55378 | 11.846352 | 0.2007092 | 0.0013034 | 1.24693 | 0.0262676 |
PC(32:0e) + H | 720.59017 | 13.029801 | 0.3277517 | 0.0079895 | 1.90627 | 0.0053236 |
PC(32:1) + H | 732.55378 | 11.612277 | 0.1923281 | 0.0046353 | 2.73062 | 0.0462711 |
PC(32:0) + H | 734.56943 | 12.360385 | 0.4178622 | 0.0068592 | 3.52812 | 0.0127862 |
PC(34:3p) + H | 740.55887 | 11.488 | 0.1531682 | 0.0021939 | 1.15239 | 0.0675083 |
PC(34:2p) + H | 742.57452 | 12.158077 | 12.690591 | 0.0175789 | 2.15496 | 0.0040868 |
PC(33:2) + H | 744.55378 | 12.829097 | 0.1222581 | 0.0301204 | 1.49374 | 0.0676107 |
PC(34:2e) + H | 744.59017 | 12.28901 | 3.1371582 | 0.0077942 | 1.67519 | 0.0831756 |
PE(18:1p/20:5) + H | 748.52757 | 11.625209 | 0.1097354 | 0.0004896 | 1.32269 | 0.0171607 |
PE(18:1p/20:4) + H | 750.54322 | 12.501618 | 0.145539 | 0.000242 | 1.19719 | 0.0083309 |
SM(d38:2) + H | 757.6218 | 12.532221 | 0.087633 | 0.000192 | 1.0073 | 0.0213935 |
PC(34:2) + H | 758.56943 | 11.630869 | 3.2335929 | 0.0364593 | 5.7643 | 0.1027676 |
PC(34:1) + H | 760.58508 | 12.445472 | 0.4729024 | 0.0141368 | 5.97923 | 0.0810498 |
PC(36:4p) + H | 766.57452 | 11.940753 | 0.2565588 | 0.0008954 | 1.12283 | 0.0060599 |
PC(36:2p) + H | 770.60582 | 12.349255 | 5.8753359 | 0.0001111 | 1.20156 | 0.1285883 |
PC(35:2) + H | 772.58508 | 12.248583 | 3.3185929 | 0.0435064 | 1.71303 | 0.0021791 |
PE(18:1p/22:4) + H | 778.57452 | 13.294718 | 0.1085165 | 4.293E-05 | 1.13316 | 0.0007308 |
PC(36:4) + H | 782.56943 | 11.487673 | 0.2070776 | 0.0001643 | 2.85354 | 0.0116555 |
PC(36:3) + H | 784.58508 | 11.748421 | 2.3365561 | 0.0049429 | 3.18958 | 0.0241481 |
PC(36:2) + H | 786.60073 | 12.677741 | 5.2284223 | 0.0029346 | 7.57054 | 0.0179213 |
PS(18:1/18:1) + H | 788.54361 | 11.642431 | 0.2881103 | 0.0102609 | 1.25586 | 0.0394853 |
PC(38:6e) + H | 792.59017 | 11.988893 | 0.1371336 | 0.0005692 | 1.11168 | 0.0054911 |
PC(38:4p) + H | 794.60582 | 12.934363 | 0.1005617 | 7.065E-05 | 1.04556 | 0.0036017 |
PC(38:6) + H | 806.56943 | 11.187251 | 0.0307172 | 0.000384 | 1.03144 | 0.0063008 |
PC(38:5) + H | 808.58508 | 11.810332 | 0.2048139 | 2.768E-05 | 1.17442 | 0.2107591 |
PC(38:5) + H | 808.58508 | 12.672307 | 5.3756449 | 0.0003799 | 2.10979 | 0.0183503 |
PC(38:5) + H | 808.58508 | 11.552074 | 0.1578107 | 0.0010544 | 2.61177 | 0.0658505 |
PC(38:4) + H | 810.60073 | 12.488833 | 0.4547764 | 0.0017399 | 2.12696 | 0.001785 |
PC(38:3) + H | 812.61638 | 12.668413 | 0.272076 | 0.0008442 | 1.10512 | 0.028863 |
PC(40:6) + H | 834.60073 | 11.597658 | 0.141325 | 0.0001152 | 1.03595 | 0.0098316 |
PC(40:6) + H | 834.60073 | 12.20053 | 0.0405773 | 5.149E-05 | 1.72933 | 0.0220091 |
PC(40:5) + H | 836.61638 | 12.501089 | 0.3850075 | 0.0014969 | 1.6471 | 0.0468449 |
TG(18:0/16:0/16:0) + NH4 | 852.80147 | 23.939109 | 2.5892204 | 0.0391508 | 1.59551 | 0.0019084 |
TG(18:0/16:0/18:0) + NH4 | 880.83277 | 24.519245 | 20.899098 | 0.0029053 | 3.16115 | 0.0048875 |
TG(18:0/18:0/18:1) + NH4 | 906.84842 | 24.538863 | 10.011565 | 0.0111865 | 1.50329 | 0.012747 |
TG(18:0/18:0/18:0) + NH4 | 908.86407 | 25.00585 | 27.739567 | 0.0034531 | 2.08332 | 0.046467 |
CerG3(d18:1/24:1) + H | 1134.7874 | 14.091305 | 0 | 0.0001224 | 1.07113 | 0.0066018 |
Cer(d18:1/24:1) + HCOO | 692.61985 | 16.175473 | 0.103872 | 0.0001471 | 1.25519 | 0.0215203 |
PE(34:2p)-H | 698.51302 | 12.449142 | 7.0769491 | 0.0006763 | 3.93889 | 0.0324108 |
PE(34:1e)-H | 702.54432 | 13.438345 | 2.0385687 | 0.0113353 | 1.156 | 0.0088682 |
PG(32:0e)-H | 707.52325 | 12.091773 | 33.793704 | 0.0061178 | 6.58985 | 0.0156174 |
PE(16:0/18:1)-H | 716.52358 | 12.720163 | 0.4202182 | 0.0004424 | 1.83386 | 0.0108465 |
PE(16:0p/20:5)-H | 720.49737 | 11.583383 | 0.1314003 | 0.0051701 | 1.44299 | 0.0107055 |
PG(16:0/16:0)-H | 721.50251 | 11.473539 | 0.0657456 | 1.681E-05 | 7.95788 | 0.0536726 |
PE(16:0p/20:4)-H | 722.51302 | 12.248596 | 0.1447987 | 2.026E-05 | 4.13162 | 0.073243 |
PE(18:1p/18:3)-H | 722.51302 | 11.479 | 0.0774059 | 0.0007414 | 2.93232 | 0.0263587 |
PE(36:3p)-H | 724.52867 | 12.689641 | 2.8785532 | 0.0012986 | 1.82325 | 0.0338385 |
PE(36:3p)-H | 724.52867 | 12.527277 | 0.1696422 | 1.244E-05 | 1.10348 | 0.0758919 |
PE(36:2p)-H | 726.54432 | 13.506758 | 2.1755145 | 0.0056018 | 3.72929 | 0.0298701 |
PG(34:0p)-H | 733.5389 | 12.13369 | 4.956339 | 0.0246676 | 2.58981 | 0.0648588 |
PG(34:0e)-H | 735.55455 | 13.058572 | 26.79393 | 0.0073044 | 1.85088 | 0.0811271 |
PE(18:1/18:1)-H | 742.53923 | 12.800264 | 0.1802797 | 2.189E-05 | 4.40304 | 0.107758 |
PE(18:0/18:1)-H | 744.55488 | 13.783132 | 0.2032096 | 0.0005934 | 2.90082 | 0.0055799 |
SM(d18:1/16:1) + HCOO | 745.55013 | 10.268659 | 0.2587852 | 0.003933 | 1.11216 | 0.0391053 |
PE(16:0p/22:6)-H | 746.51302 | 11.933663 | 0.0081673 | 0.0009601 | 2.06975 | 0.037648 |
PG(16:0/18:1)-H | 747.51816 | 11.589231 | 0.2997752 | 0.0061899 | 1.95396 | 0.0031406 |
PG(16:0/18:1)-H | 747.51816 | 12.082 | 0.0070412 | 0.0001049 | 1.70948 | 0.0101288 |
SM(d18:1/16:0) + HCOO | 747.56578 | 11.143139 | 3.1337131 | 0.0163085 | 1.20354 | 0.1452831 |
PE(16:0p/22:5)-H | 748.52867 | 12.289308 | 0.0987534 | 8.502E-05 | 3.64684 | 0.0068211 |
PE(18:0p/20:5)-H | 748.52867 | 12.567227 | 0.1766982 | 0.0002361 | 1.83825 | 0.009736 |
PG(18:0/16:0)-H | 749.53381 | 12.425961 | 0.1646077 | 5.421E-05 | 2.56412 | 0.0199873 |
SM(d18:0/16:0) + HCOO | 749.58143 | 11.7146 | 0.3821158 | 0.0016634 | 1.98624 | 0.0581853 |
PE(18:0p/20:4)-H | 750.54432 | 13.279505 | 0.2216461 | 5.222E-05 | 3.07046 | 0.0127945 |
PE(16:0p/22:4)-H | 750.54432 | 12.97263 | 0.0866529 | 3.018E-05 | 1.93611 | 0.0087864 |
PC(16:0p/16:0) + HCOO | 762.56545 | 12.873873 | 0.1047239 | 0.0025272 | 1.16224 | 0.0074952 |
PE(18:1/20:4)-H | 764.52358 | 11.833072 | 0.0198255 | 2.089E-05 | 2.0106 | 0.0174142 |
PE(18:0/20:5)-H | 764.52358 | 12.138 | 0.0074497 | 0.0003435 | 1.20561 | 0.0241654 |
PE(18:0/20:4)-H | 766.53923 | 12.75693 | 0.0375343 | 4.79E-06 | 3.30905 | 0.1177161 |
PE(18:0/20:3)-H | 768.55488 | 13.193352 | 0.0522966 | 0.003736 | 1.16198 | 0.0061066 |
PE(20:1/18:1)-H | 770.57053 | 13.784833 | 0.0493772 | 0.0002845 | 1.56243 | 0.0107648 |
PE(18:1p/22:6)-H | 772.52867 | 12.002327 | 0.010826 | 0.0002546 | 1.51339 | 0.0270652 |
PS(36:2e)-H | 772.5498 | 11.450658 | #DIV/0! | 7.631E-05 | 1.33306 | 0.0013688 |
SM(d18:1/18:1) + HCOO | 773.58143 | 11.463026 | 0.2381133 | 0.0003138 | 1.47317 | 0.0137748 |
PE(18:0p/22:6)-H | 774.54432 | 12.944895 | 0.0248033 | 7.927E-05 | 1.9671 | 0.0044874 |
PE(18:1p/22:5)-H | 774.54432 | 12.319588 | 0.0451147 | 0.0005202 | 1.26561 | 0.0308905 |
SM(d18:0/18:1) + HCOO | 775.59708 | 12.38504 | 0.2961012 | 0.0003765 | 2.84705 | 0.0099288 |
PE(18:0p/22:5)-H | 776.55997 | 13.285239 | 0.1177648 | 2.278E-05 | 1.95952 | 0.0080996 |
PE(18:1p/22:4)-H | 776.55997 | 13.012059 | 0.0459673 | 6.588E-05 | 1.21688 | 0.0024014 |
PG(18:0/18:0)-H | 777.56511 | 13.412865 | 0.1266703 | 4.927E-05 | 1.43803 | 0.0305797 |
SM(d18:0/18:0) + HCOO | 777.61273 | 12.769534 | 0.1442123 | 4.697E-05 | 1.23292 | 0.0171988 |
PE(18:0p/22:4)-H | 778.57562 | 14.047477 | 0.107071 | 2.975E-05 | 1.1974 | 0.0061423 |
PS(18:0/18:1)-H | 788.54471 | 12.473056 | 0.3286841 | 0.0297073 | 2.66766 | 0.016332 |
SM(d22:1/16:0) + HCOO | 803.62838 | 13.458944 | 0.2784275 | 0.0002187 | 1.11001 | 0.0696966 |
PS(18:0/20:4)-H | 810.52906 | 11.58011 | 0.0645448 | 0.0001105 | 1.45732 | 0.0093627 |
PS(18:0/20:3)-H | 812.54471 | 11.97813 | 0.0967219 | 0.0004739 | 1.80055 | 0.0917789 |
PS(20:1/18:1)-H | 814.56036 | 12.487242 | 0.0604681 | 0.002872 | 1.35476 | 0.0169701 |
PC(18:0e/18:1) + HCOO | 818.62805 | 14.214201 | 2.2124072 | 0.0456916 | 1.2273 | 0.0203368 |
SM(d22:1/18:1) + HCOO | 829.64403 | 13.588027 | 0.1901319 | 0.002038 | 1.56036 | 0.0645059 |
MGDG(40:5)-H | 831.59917 | 12.658 | 2.6826723 | 0.0060226 | 3.97242 | 0.0061761 |
SM(d22:1/18:0) + HCOO | 831.65968 | 14.596852 | 0.4635037 | 0.007412 | 1.82634 | 0.0147283 |
PC(18:0/18:1) + HCOO | 832.60731 | 12.864 | 1.924755 | 0.0336785 | 1.82967 | 0.0768031 |
PS(18:0/22:6)-H | 834.52906 | 11.311759 | 0.0071894 | 0.0001123 | 1.4428 | 0.00347 |
PS(18:0/22:5)-H | 836.54471 | 11.595335 | 0.0667759 | 0.0001863 | 1.29217 | 0.0258396 |
PC(18:1/20:4) + HCOO | 852.57601 | 11.52204 | 0.2125022 | 5.243E-05 | 1.16355 | 0.0111386 |
SM(d42:3) + HCOO | 855.65968 | 13.525602 | 0.1063234 | 0.0001879 | 2.9138 | 0.0199491 |
SM(d42:2) + HCOO | 857.67533 | 13.545112 | 0.0942641 | 9.483E-05 | 1.18221 | 0.0006172 |
SM(d22:1/20:1) + HCOO | 857.67533 | 14.526616 | 0.167393 | 0.000104 | 5.06469 | 0.0136233 |
SM(d42:2) + HCOO | 857.67533 | 14.727306 | 0.252808 | 0.001211 | 1.75892 | 0.023403 |
SM(d42:1) + HCOO | 859.69098 | 14.966437 | 0.0806861 | 0.0003376 | 1.01072 | 0.0182043 |
PI(18:0/20:4)-H | 885.54986 | 11.369021 | 0.1675608 | 0.0003305 | 2.32953 | 0.0672784 |
GM3(d34:1)-H | 1151.7059 | 9.9060133 | 12.292786 | 0.001588 | 1.16125 | 0.126017 |
GM3(d42:1)-H | 1263.8311 | 13.772293 | 8.9902052 | 0.0008371 | 1.08214 | 0.0259905 |