Table 3 Candidate drugs targeted by the hub genes

1

TYMS

ETOPOSIDE

–

PharmGKB

–

2

TYMS

IRINOTECAN

–

CIViC

20,628,391

3

TYMS

VINCRISTINE

–

NCI

2,804,079

4

TYMS

FOLIC ACID

–

PharmGKB

–

5

TYMS

TOPOTECAN

–

NCI

10,803,925

6

TYMS

CYTARABINE

–

PharmGKB

–

7

TYMS

MITOMYCIN

–

NCI

15,218,314

8

TYMS

PREDNISONE

–

PharmGKB

–

9

TYMS

TRIFLURIDINE

inhibitor

DrugBank

18,600,528; 16,902,987; 20,372,850; 19,816,940; 19,886,911; 4,719,131; 6,436,227; 15,571,283; 17,179,993; 14,719,072; 16,010,590; 15,125,867; 11,752,352; 18,798,063; 6,010,427

10

TYMS

DAUNORUBICIN

–

NCI

2,967,076

11

TYMS

HYDROCORTISONE

–

NCI

2,707,640

12

TYMS

PRALATREXATE

inhibitor

DrugBank

23,409,799

13

TYMS

PHENTOLAMINE

–

NCI

2,866,100

14

TYMS

TRIMETHOPRIM

inhibitor

DrugBank

8,538,681; 10,090,784; 10,592,235; 17,139,284; 8,920,005; 17,016,423; 19,622,858

15

TYMS

INDOMETHACIN

–

NCI

2,707,640

16

TYMS

GEMCITABINE

inhibitor

DrugBank

16,563,096; 15,795,320; 17,166,391; 16,818,276; 11,752,352; 15,655,942; 16,818,496

17

TYMS

ASPARAGINASE

–

PharmGKB

–

18

TYMS

CAPECITABINE

inhibitor

ClearityFoundationBiomarkers; ClearityFoundationClinicalTrial; GuideToPharmacologyInteractions; ChemblInteractions; DrugBank

15,134,221; 16,926,630; 15,866,500; 15,132,128; 11,752,352; 15,709,193

19

TYMS

FLOXURIDINE

inhibitor

TdgClinicalTrial; ClearityFoundationClinicalTrial; ChemblInteractions; TEND; DrugBank

10,697,523; 10,891,536; 10,697,524; 10,482,907; 10,553,409

20

TYMS

LEUCOVORIN

–

TdgClinicalTrial; TEND

–

21

TYMS

TAMOXIFEN

–

NCI

9,615,734

22

TYMS

VERAPAMIL

–

NCI

3,436,366

23

TYMS

RALTITREXED

inhibitor

PharmGKB; TdgClinicalTrial; GuideToPharmacologyInteractions; TEND; DrugBank

18,773,878; 10,598,555; 10,430,100; 10,592,235; 11,752,352; 10,499,608; 10,482,907; 10,047,461; 10,496,350

24

TYMS

PEMETREXED DISODIUM

inhibitor

ChemblInteractions

–

25

TYMS

DEXAMETHASONE

–

NCI

2,707,640; 3,398,844

26

TYMS

INTERFERON GAMA-1B

–

NCI

1,557,656

27

TYMS

FLUOROURACIL

inhibitor

ClearityFoundationClinicalTrial; ChemblInteractions; CIViC; DrugBank

16,563,096; 20,628,391; 16,609,021; 16,719,540; 16,596,248; 16,538,493; 11,752,352; 15,353,299

28

TYMS

OXALIPLATIN

–

PharmGKB

–

29

TYMS

TEGAFUR

–

TdgClinicalTrial

–

30

TYMS

SULFASALAZINE

–

PharmGKB

–

31

TYMS

PEMETREXED (CHEMBL1201258)

inhibitor

ClearityFoundationBiomarkers; TdgClinicalTrial; GuideToPharmacologyInteractions; CIViC; TEND

23,645,741; 23,060,591; 21,367,480; 26,502,926

32

TYMS

METHOTREXATE

–

CIViC

23,652,803

33

BIRC5

IRINOTECAN

–

NCI

15,956,246

34

BIRC5

INTERFERON BETA-1A

–

NCI

12,117,359

35

BIRC5

DOXORUBICIN

–

NCI

16,211,302

36

BIRC5

CYTARABINE

–

NCI

14,713,572

37

BIRC5

TRASTUZUMAB

–

NCI|CIViC

16,452,223; 23,204,226

38

BIRC5

LAPATINIB

–

NCI

16,452,223

39

BIRC5

PROXYPHYLLINE

–

NCI

12,895,357

40

BIRC5

PACLITAXEL

–

ClearityFoundationBiomarkers; NCI

16,211,241; 15,347,474

41

BIRC5

DOCETAXEL

–

ClearityFoundationBiomarkers

–

42

BIRC5

FLUTAMIDE

–

NCI

15,735,703

43

BIRC5

VORINOSTAT

–

NCI

16,951,239

44

BIRC5

PRASTERONE

–

NCI

16,461,558

45

BIRC5

ARSENIC TRIOXIDE

–

NCI

15,587,394; 16,950,207

46

BIRC5

ERLOTINIB

–

NCI

17,047,074

47

BIRC5

INDOMETHACIN

–

NCI

17,270,149

48

BIRC5

IMATINIB

–

NCI

16,254,145

49

BIRC5

ROMIDEPSIN

–

NCI

14,767,553

50

BIRC5

EPIRUBICIN

–

NCI

16,608,080

51

BIRC5

PLICAMYCIN

–

NCI

17,124,180

52

BIRC5

OMACETAXINE MEPESUCCINATE

–

NCI

15,854,289

53

BIRC5

MYCOPHENOLIC ACID

–

NCI

15,571,295

54

BIRC5

DEXAMETHASONE

–

NCI

16,787,583

55

BIRC5

FLUOROURACIL

–

NCI

15,067,352

56

BIRC5

DACTINOMYCIN

–

NCI

15,883,285

57

BIRC5

CALCITONIN

–

NCI

16,222,118

58

BIRC5

CARBOPLATIN

–

NCI

15,347,474

59

BIRC5

EPOETIN ALFA

–

NCI

17,112,829

60

BIRC5

TRETINOIN

–

NCI

11,939,262; 14,587,026; 16,403,261

61

BIRC5

METHOTREXATE

–

NCI

15,670,151

62

BIRC5

SULINDAC

–

NCI

16,707,021; 16,950,207