TY - STD TI - Ovarian Cancer Statistics: Center for disease control and prevention; [updated June 8, 2020. Available from: https://www.cdc.gov/cancer/ovarian/statistics/index.htm. UR - https://www.cdc.gov/cancer/ovarian/statistics/index.htm ID - ref1 ER - TY - JOUR AU - Yeung, T. L. AU - Leung, C. S. AU - Yip, K. P. AU - Au Yeung, C. L. AU - Wong, S. T. AU - Mok, S. C. PY - 2015 DA - 2015// TI - Cellular and molecular processes in ovarian cancer metastasis. A review in the theme: cell and molecular processes in cancer metastasis JO - Am J Physiol Cell Physiol. VL - 309 UR - https://doi.org/10.1152/ajpcell.00188.2015 DO - 10.1152/ajpcell.00188.2015 ID - Yeung2015 ER - TY - JOUR AU - Guan, L. Y. AU - Lu, Y. PY - 2018 DA - 2018// TI - New developments in molecular targeted therapy of ovarian cancer JO - Discov Med VL - 26 ID - Guan2018 ER - TY - JOUR AU - Aghamiri, S. AU - Mehrjardi, K. F. AU - Shabani, S. AU - Keshavarz-Fathi, M. AU - Kargar, S. AU - Rezaei, N. PY - 2019 DA - 2019// TI - Nanoparticle-siRNA: a potential strategy for ovarian cancer therapy? JO - Nanomedicine (Lond) VL - 14 UR - https://doi.org/10.2217/nnm-2018-0379 DO - 10.2217/nnm-2018-0379 ID - Aghamiri2019 ER - TY - JOUR AU - Delage, B. AU - Fennell, D. A. AU - Nicholson, L. AU - McNeish, I. AU - Lemoine, N. R. AU - Crook, T. PY - 2010 DA - 2010// TI - Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer JO - Int J Cancer VL - 126 ID - Delage2010 ER - TY - JOUR AU - Fung, M. K. L. AU - Chan, G. C. PY - 2017 DA - 2017// TI - Drug-induced amino acid deprivation as strategy for cancer therapy JO - J Hematol Oncol VL - 10 UR - https://doi.org/10.1186/s13045-017-0509-9 DO - 10.1186/s13045-017-0509-9 ID - Fung2017 ER - TY - JOUR AU - Zou, S. AU - Wang, X. AU - Liu, P. AU - Ke, C. AU - Xu, S. PY - 2019 DA - 2019// TI - Arginine metabolism and deprivation in cancer therapy JO - Biomed Pharmacother VL - 118 UR - https://doi.org/10.1016/j.biopha.2019.109210 DO - 10.1016/j.biopha.2019.109210 ID - Zou2019 ER - TY - JOUR AU - Al-Koussa, H. AU - Mais, N. AU - Maalouf, H. AU - Abi-Habib, R. AU - El-Sibai, M. PY - 2020 DA - 2020// TI - Arginine deprivation: a potential therapeutic for cancer cell metastasis? A review JO - Cancer Cell Int VL - 20 UR - https://doi.org/10.1186/s12935-020-01232-9 DO - 10.1186/s12935-020-01232-9 ID - Al-Koussa2020 ER - TY - STD TI - Al-Koussa H, Al-Haddad M, Abi-Habib R, El-Sibai M. Human recombinant arginase I [HuArgI (Co)-PEG5000]-Induced arginine depletion inhibits colorectal cancer cell migration and invasion. Int J Mol Sci. 2019;20(23):6018. https://doi.org/10.3390/ijms20236018. ID - ref9 ER - TY - STD TI - Khalil N, Abi-Habib RJ. [HuArgI (co)-PEG5000]-induced arginine deprivation leads to autophagy dependent cell death in pancreatic cancer cells. Invest New Drugs. 2020;38(5):1236-46. https://doi.org/10.1007/s10637-019-00883-4. Epub 2019 Dec 10. ID - ref10 ER - TY - JOUR AU - Khoury, O. AU - Ghazale, N. AU - Stone, E. AU - El-Sibai, M. AU - Frankel, A. E. AU - Abi-Habib, R. J. PY - 2015 DA - 2015// TI - Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells JO - J Neuro-Oncol VL - 122 UR - https://doi.org/10.1007/s11060-014-1698-5 DO - 10.1007/s11060-014-1698-5 ID - Khoury2015 ER - TY - JOUR AU - Tanios, R. AU - Bekdash, A. AU - Kassab, E. AU - Stone, E. AU - Georgiou, G. AU - Frankel, A. E. PY - 2013 DA - 2013// TI - Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human acute myeloid leukemia cells JO - Leuk Res VL - 37 UR - https://doi.org/10.1016/j.leukres.2013.08.007 DO - 10.1016/j.leukres.2013.08.007 ID - Tanios2013 ER - TY - JOUR AU - Nasreddine, G. AU - El-Sibai, M. AU - Abi-Habib, R. J. PY - 2020 DA - 2020// TI - Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent JO - Investig New Drugs VL - 38 UR - https://doi.org/10.1007/s10637-019-00756-w DO - 10.1007/s10637-019-00756-w ID - Nasreddine2020 ER - TY - JOUR AU - Gupta, G. P. AU - Massagué, J. PY - 2006 DA - 2006// TI - Cancer metastasis: building a framework JO - Cell. VL - 127 UR - https://doi.org/10.1016/j.cell.2006.11.001 DO - 10.1016/j.cell.2006.11.001 ID - Gupta2006 ER - TY - JOUR AU - Hanahan, D. AU - Weinberg, R. A. PY - 2011 DA - 2011// TI - Hallmarks of cancer: the next generation JO - Cell. VL - 144 UR - https://doi.org/10.1016/j.cell.2011.02.013 DO - 10.1016/j.cell.2011.02.013 ID - Hanahan2011 ER - TY - JOUR AU - Zeeshan, R. AU - Mutahir, Z. PY - 2017 DA - 2017// TI - Cancer metastasis - tricks of the trade JO - Bosn J Basic Med Sci VL - 17 ID - Zeeshan2017 ER - TY - JOUR AU - Saykali, B. A. AU - El-Sibai, M. PY - 2014 DA - 2014// TI - Invadopodia, regulation, and assembly in cancer cell invasion JO - Cell Commun Adhes VL - 21 UR - https://doi.org/10.3109/15419061.2014.923845 DO - 10.3109/15419061.2014.923845 ID - Saykali2014 ER - TY - JOUR AU - Parsons, J. T. AU - Horwitz, A. R. AU - Schwartz, M. A. PY - 2010 DA - 2010// TI - Cell adhesion: integrating cytoskeletal dynamics and cellular tension JO - Nat Rev Mol Cell Biol VL - 11 UR - https://doi.org/10.1038/nrm2957 DO - 10.1038/nrm2957 ID - Parsons2010 ER - TY - JOUR AU - Gardel, M. L. AU - Schneider, I. C. AU - Aratyn-Schaus, Y. AU - Waterman, C. M. PY - 2010 DA - 2010// TI - Mechanical integration of actin and adhesion dynamics in cell migration JO - Annu Rev Cell Dev Biol VL - 26 UR - https://doi.org/10.1146/annurev.cellbio.011209.122036 DO - 10.1146/annurev.cellbio.011209.122036 ID - Gardel2010 ER - TY - JOUR AU - Yamaguchi, H. AU - Pixley, F. AU - Condeelis, J. PY - 2006 DA - 2006// TI - Invadopodia and podosomes in tumor invasion JO - Eur J Cell Biol VL - 85 UR - https://doi.org/10.1016/j.ejcb.2005.10.004 DO - 10.1016/j.ejcb.2005.10.004 ID - Yamaguchi2006 ER - TY - JOUR AU - Bailly, M. AU - Condeelis, J. PY - 2002 DA - 2002// TI - Cell motility: insights from the backstage JO - Nat Cell Biol VL - 4 UR - https://doi.org/10.1038/ncb1202-e292 DO - 10.1038/ncb1202-e292 ID - Bailly2002 ER - TY - JOUR AU - Banyard, J. AU - Anand-Apte, B. AU - Symons, M. AU - Zetter, B. R. PY - 2000 DA - 2000// TI - Motility and invasion are differentially modulated by rho family GTPases JO - Oncogene. VL - 19 UR - https://doi.org/10.1038/sj.onc.1203338 DO - 10.1038/sj.onc.1203338 ID - Banyard2000 ER - TY - JOUR AU - Alan, J. K. AU - Lundquist, E. A. PY - 2013 DA - 2013// TI - Mutationally activated rho GTPases in cancer JO - Small GTPases VL - 4 UR - https://doi.org/10.4161/sgtp.26530 DO - 10.4161/sgtp.26530 ID - Alan2013 ER - TY - JOUR AU - Etienne-Manneville, S. AU - Hall, A. PY - 2002 DA - 2002// TI - Rho GTPases in cell biology JO - Nature. VL - 420 UR - https://doi.org/10.1038/nature01148 DO - 10.1038/nature01148 ID - Etienne-Manneville2002 ER - TY - JOUR AU - Hall, A. PY - 1998 DA - 1998// TI - Rho GTPases and the actin cytoskeleton JO - Science. VL - 279 UR - https://doi.org/10.1126/science.279.5350.509 DO - 10.1126/science.279.5350.509 ID - Hall1998 ER - TY - JOUR AU - Hanna, S. AU - El-Sibai, M. PY - 2013 DA - 2013// TI - Signaling networks of rho GTPases in cell motility JO - Cell Signal VL - 25 UR - https://doi.org/10.1016/j.cellsig.2013.04.009 DO - 10.1016/j.cellsig.2013.04.009 ID - Hanna2013 ER - TY - JOUR AU - Al-Koussa, H. AU - Atat, O. E. AU - Jaafar, L. AU - Tashjian, H. AU - El-Sibai, M. PY - 2020 DA - 2020// TI - The role of Rho GTPases in motility and invasion of glioblastoma cells JO - Anal Cell Pathol (Amst) VL - 2020 ID - Al-Koussa2020 ER - TY - JOUR AU - Svensmark, J. H. AU - Brakebusch, C. PY - 2019 DA - 2019// TI - Rho GTPases in cancer: friend or foe? JO - Oncogene. VL - 38 UR - https://doi.org/10.1038/s41388-019-0963-7 DO - 10.1038/s41388-019-0963-7 ID - Svensmark2019 ER - TY - JOUR AU - Hanna, S. AU - Khalil, B. AU - Nasrallah, A. AU - Saykali, B. A. AU - Sobh, R. AU - Nasser, S. PY - 2014 DA - 2014// TI - StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion JO - Int J Oncol VL - 44 UR - https://doi.org/10.3892/ijo.2014.2330 DO - 10.3892/ijo.2014.2330 ID - Hanna2014 ER - TY - JOUR AU - Khalil, B. D. AU - Hanna, S. AU - Saykali, B. A. AU - El-Sitt, S. AU - Nasrallah, A. AU - Marston, D. PY - 2014 DA - 2014// TI - The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility JO - Exp Cell Res VL - 321 UR - https://doi.org/10.1016/j.yexcr.2013.11.023 DO - 10.1016/j.yexcr.2013.11.023 ID - Khalil2014 ER - TY - JOUR AU - Nasrallah, A. AU - Saykali, B. AU - Dimassi, S. AU - Khoury, N. AU - Hanna, S. AU - El-Sibai, M. PY - 2014 DA - 2014// TI - Effect of StarD13 on colorectal cancer proliferation, motility and invasion JO - Oncol Rep VL - 31 UR - https://doi.org/10.3892/or.2013.2861 DO - 10.3892/or.2013.2861 ID - Nasrallah2014 ER - TY - STD TI - Nicolas S, Abdellatef S, Haddad MA, Fakhoury I, El-Sibai M. Hypoxia and EGF stimulation regulate VEGF expression in human glioblastoma multiforme (GBM) Cells by differential regulation of the PI3K/Rho-GTPase and MAPK pathways. Cells. 2019;8(11):1397. https://doi.org/10.3390/cells8111397. ID - ref32 ER - TY - JOUR AU - Horzum, U. AU - Ozdil, B. AU - Pesen-Okvur, D. PY - 2014 DA - 2014// TI - Step-by-step quantitative analysis of focal adhesions JO - MethodsX. VL - 1 UR - https://doi.org/10.1016/j.mex.2014.06.004 DO - 10.1016/j.mex.2014.06.004 ID - Horzum2014 ER - TY - JOUR AU - Kenific, C. M. AU - Wittmann, T. AU - Debnath, J. PY - 2016 DA - 2016// TI - Autophagy in adhesion and migration JO - J Cell Sci VL - 129 UR - https://doi.org/10.1242/jcs.188490 DO - 10.1242/jcs.188490 ID - Kenific2016 ER - TY - JOUR AU - Sharifi, M. N. AU - Mowers, E. E. AU - Drake, L. E. AU - Collier, C. AU - Chen, H. AU - Zamora, M. PY - 2016 DA - 2016// TI - Autophagy promotes focal adhesion disassembly and cell motility of metastatic tumor cells through the direct interaction of Paxillin with LC3 JO - Cell Rep VL - 15 UR - https://doi.org/10.1016/j.celrep.2016.04.065 DO - 10.1016/j.celrep.2016.04.065 ID - Sharifi2016 ER - TY - JOUR AU - Xu, Z. AU - Klionsky, D. J. PY - 2016 DA - 2016// TI - Autophagy promotes cell motility by driving focal adhesion turnover JO - Autophagy. VL - 12 UR - https://doi.org/10.1080/15548627.2016.1212791 DO - 10.1080/15548627.2016.1212791 ID - Xu2016 ER - TY - JOUR AU - Yoshida, T. AU - Tsujioka, M. AU - Honda, S. AU - Tanaka, M. AU - Shimizu, S. PY - 2016 DA - 2016// TI - Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF JO - Oncotarget. VL - 7 UR - https://doi.org/10.18632/oncotarget.8883 DO - 10.18632/oncotarget.8883 ID - Yoshida2016 ER - TY - JOUR AU - Feun, L. G. AU - Kuo, M. T. AU - Savaraj, N. PY - 2015 DA - 2015// TI - Arginine deprivation in cancer therapy JO - Curr Opin Clin Nutr Metab Care VL - 18 UR - https://doi.org/10.1097/MCO.0000000000000122 DO - 10.1097/MCO.0000000000000122 ID - Feun2015 ER - TY - JOUR AU - Huang, C. C. AU - Tsai, S. T. AU - Kuo, C. C. AU - Chang, J. S. AU - Jin, Y. T. AU - Chang, J. Y. PY - 2012 DA - 2012// TI - Arginine deprivation as a new treatment strategy for head and neck cancer JO - Oral Oncol VL - 48 UR - https://doi.org/10.1016/j.oraloncology.2012.06.004 DO - 10.1016/j.oraloncology.2012.06.004 ID - Huang2012 ER - TY - JOUR AU - Pavlyk, I. AU - Rzhepetskyy, Y. AU - Jagielski, A. K. AU - Drozak, J. AU - Wasik, A. AU - Pereverzieva, G. PY - 2015 DA - 2015// TI - Arginine deprivation affects glioblastoma cell adhesion, invasiveness and actin cytoskeleton organization by impairment of β-actin arginylation JO - Amino Acids VL - 47 UR - https://doi.org/10.1007/s00726-014-1857-1 DO - 10.1007/s00726-014-1857-1 ID - Pavlyk2015 ER - TY - JOUR AU - Wang, H. AU - Li, Q. F. AU - Chow, H. Y. AU - Choi, S. C. AU - Leung, Y. C. PY - 2020 DA - 2020// TI - Arginine deprivation inhibits pancreatic cancer cell migration, invasion and EMT via the down regulation of snail, slug, twist, and MMP1/9 JO - J Physiol Biochem VL - 76 UR - https://doi.org/10.1007/s13105-019-00716-1 DO - 10.1007/s13105-019-00716-1 ID - Wang2020 ER - TY - JOUR AU - Kutys, M. L. AU - Doyle, A. D. AU - Yamada, K. M. PY - 2013 DA - 2013// TI - Regulation of cell adhesion and migration by cell-derived matrices JO - Exp Cell Res VL - 319 UR - https://doi.org/10.1016/j.yexcr.2013.05.030 DO - 10.1016/j.yexcr.2013.05.030 ID - Kutys2013 ER - TY - JOUR AU - Chandra, S. AU - Romero, M. J. AU - Shatanawi, A. AU - Alkilany, A. M. AU - Caldwell, R. B. AU - Caldwell, R. W. PY - 2012 DA - 2012// TI - Oxidative species increase arginase activity in endothelial cells through the RhoA/rho kinase pathway JO - Br J Pharmacol VL - 165 UR - https://doi.org/10.1111/j.1476-5381.2011.01584.x DO - 10.1111/j.1476-5381.2011.01584.x ID - Chandra2012 ER - TY - JOUR AU - Ming, X. F. AU - Barandier, C. AU - Viswambharan, H. AU - Kwak, B. R. AU - Mach, F. AU - Mazzolai, L. PY - 2004 DA - 2004// TI - Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction JO - Circulation. VL - 110 UR - https://doi.org/10.1161/01.CIR.0000142867.26182.32 DO - 10.1161/01.CIR.0000142867.26182.32 ID - Ming2004 ER - TY - JOUR AU - Shatanawi, A. AU - Romero, M. J. AU - Iddings, J. A. AU - Chandra, S. AU - Umapathy, N. S. AU - Verin, A. D. PY - 2011 DA - 2011// TI - Angiotensin II-induced vascular endothelial dysfunction through RhoA/rho kinase/p38 mitogen-activated protein kinase/arginase pathway JO - Am J Physiol Cell Physiol VL - 300 UR - https://doi.org/10.1152/ajpcell.00328.2010 DO - 10.1152/ajpcell.00328.2010 ID - Shatanawi2011 ER - TY - JOUR AU - Toque, H. A. AU - Nunes, K. P. AU - Yao, L. AU - Liao, J. K. AU - Webb, R. C. AU - Caldwell, R. B. PY - 2013 DA - 2013// TI - Activated rho kinase mediates diabetes-induced elevation of vascular arginase activation and contributes to impaired corpora cavernosa relaxation: possible involvement of p38 MAPK activation JO - J Sex Med VL - 10 UR - https://doi.org/10.1111/jsm.12134 DO - 10.1111/jsm.12134 ID - Toque2013 ER - TY - JOUR AU - Tratsiakovich, Y. AU - Kiss, A. AU - Gonon, A. T. AU - Yang, J. AU - Sjöquist, P. O. AU - Pernow, J. PY - 2017 DA - 2017// TI - Inhibition of rho kinase protects from ischaemia-reperfusion injury via regulation of arginase activity and nitric oxide synthase in type 1 diabetes JO - Diab Vasc Dis Res VL - 14 UR - https://doi.org/10.1177/1479164116687935 DO - 10.1177/1479164116687935 ID - Tratsiakovich2017 ER - TY - JOUR AU - Tkach, V. AU - Bock, E. AU - Berezin, V. PY - 2005 DA - 2005// TI - The role of RhoA in the regulation of cell morphology and motility JO - Cell Motil Cytoskeleton VL - 61 UR - https://doi.org/10.1002/cm.20062 DO - 10.1002/cm.20062 ID - Tkach2005 ER - TY - JOUR AU - Mowers, E. E. AU - Sharifi, M. N. AU - Macleod, K. F. PY - 2017 DA - 2017// TI - Autophagy in cancer metastasis JO - Oncogene. VL - 36 UR - https://doi.org/10.1038/onc.2016.333 DO - 10.1038/onc.2016.333 ID - Mowers2017 ER - TY - JOUR AU - Pan, X. AU - Wang, C. AU - Li, Y. AU - Zhu, L. AU - Zhang, T. PY - 2018 DA - 2018// TI - Protective autophagy induced by physcion suppresses hepatocellular carcinoma cell metastasis by inactivating the JAK2/STAT3 Axis JO - Life Sci VL - 214 UR - https://doi.org/10.1016/j.lfs.2018.10.064 DO - 10.1016/j.lfs.2018.10.064 ID - Pan2018 ER - TY - JOUR AU - Tsai, C. H. AU - Li, C. H. AU - Cheng, Y. W. AU - Lee, C. C. AU - Liao, P. L. AU - Lin, C. H. PY - 2017 DA - 2017// TI - The inhibition of lung cancer cell migration by AhR-regulated autophagy JO - Sci Rep VL - 7 UR - https://doi.org/10.1038/srep41927 DO - 10.1038/srep41927 ID - Tsai2017 ER - TY - JOUR AU - Belaid, A. AU - Ndiaye, P. D. AU - Cerezo, M. AU - Cailleteau, L. AU - Brest, P. AU - Klionsky, D. J. PY - 2014 DA - 2014// TI - Autophagy and SQSTM1 on the RHOA(d) again: emerging roles of autophagy in the degradation of signaling proteins JO - Autophagy. VL - 10 UR - https://doi.org/10.4161/auto.27198 DO - 10.4161/auto.27198 ID - Belaid2014 ER -