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Table 4 AUC and test characteristics of different androgens for representing hyperandrogenemia in PCOS patients using ROC analysis

From: Comparison of the efficacy of different androgens measured by LC-MS/MS in representing hyperandrogenemia and an evaluation of adrenal-origin androgens with a dexamethasone suppression test in patients with PCOS

Androgens AUC 95% CI Z value P value Optimal cutoff value of androgens Sensitivity (95% CI) Specificity (95% CI) Positive predictive value (95% CI) Negative predictive value (95% CI) Positive LR (95% CI) Negative LR (95% CI)
TT 0.816 0.742–0.876 8.894 < 0.001 0.337 72.0 (62.1–80.5) 82.93 (67.9–92.8) 91.1 (82.6–96.3) 54.8 (41.7–67.5) 4.22 (3.5–5.1) 0.34 (0.2–0.7)
AD 0.842 0.771–0.898 10.489 < 0.001 1.309 81.0 (71.9–88.2) 73.17 (57.1–85.8) 88.0 (79.6–93.9) 61.2 (46.2–74.8) 3.02 (2.5–3.7) 0.26 (0.1–0.3)
DHEA-S 0.678 ac 0.594–0.754 3.792 < 0.001 1887.057 86.0 (77.6–92.1) 48.78 (32.9–64.9) 80.4 (71.6–87.4) 58.8 (40.7–75.3) 1.68 (1.2–2.3) 0.29 (0.2–0.5)
FAI 0.937 bcd 0.883–0.971 22.389 < 0.001 2.50 87.0 (78.8–92.9) 92.68 (80.1–98.4) 96.7 (90.6–99.3) 74.5 (60.4–85.7) 11.89 (10.6–13.3) 0.14 (0.04–0.5)
  1. Compared with AUCTT, a: P < 0.01, b: P< 0.001
  2. Compared with AUCAD, c: P< 0.001
  3. Compared with AUCDHEA-S, d: P< 0.001
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