Table 4 AUC and test characteristics of different androgens for representing hyperandrogenemia in PCOS patients using ROC analysis
Androgens | AUC | 95% CI | Z value | P value | Optimal cutoff value of androgens | Sensitivity (95% CI) | Specificity (95% CI) | Positive predictive value (95% CI) | Negative predictive value (95% CI) | Positive LR (95% CI) | Negative LR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|
TT | 0.816 | 0.742–0.876 | 8.894 | < 0.001 | 0.337 | 72.0 (62.1–80.5) | 82.93 (67.9–92.8) | 91.1 (82.6–96.3) | 54.8 (41.7–67.5) | 4.22 (3.5–5.1) | 0.34 (0.2–0.7) |
AD | 0.842 | 0.771–0.898 | 10.489 | < 0.001 | 1.309 | 81.0 (71.9–88.2) | 73.17 (57.1–85.8) | 88.0 (79.6–93.9) | 61.2 (46.2–74.8) | 3.02 (2.5–3.7) | 0.26 (0.1–0.3) |
DHEA-S | 0.678 ac | 0.594–0.754 | 3.792 | < 0.001 | 1887.057 | 86.0 (77.6–92.1) | 48.78 (32.9–64.9) | 80.4 (71.6–87.4) | 58.8 (40.7–75.3) | 1.68 (1.2–2.3) | 0.29 (0.2–0.5) |
FAI | 0.937 bcd | 0.883–0.971 | 22.389 | < 0.001 | 2.50 | 87.0 (78.8–92.9) | 92.68 (80.1–98.4) | 96.7 (90.6–99.3) | 74.5 (60.4–85.7) | 11.89 (10.6–13.3) | 0.14 (0.04–0.5) |