Table 2 Risk factors for overall survival of PPSC patients by univariate and multivariate analyses
Clinical features | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Age | ||||||
≤ 49 | Reference | – | – | Reference | – | – |
50–69 | 1.70 | 0.99–2.92 | 0.056 | 1.66 | 0.96–2.85 | 0.069 |
≥ 70 | 2.71 | 1.57–4.67 | < 0.001 | 2.49 | 1.44–4.31 | 0.001 |
Race | ||||||
White | Reference | – | – | |||
Black | 1.20 | 0.75–1.90 | 0.445 | |||
others | 0.84 | 0.59–1.18 | 0.317 | |||
Marital status | ||||||
Married | Reference | – | – | Reference | – | – |
Not married | 1.37 | 1.12–1.68 | 0.003 | 1.22 | 0.99–1.51 | 0.061 |
Unknown | 1.31 | 0.76–2.25 | 0.330 | 1.13 | 0.65–1.96 | 0.676 |
Tumor grade | ||||||
I | Reference | – | – | Reference | – | – |
II | 3.65 | 1.15–11.82 | 0.028 | 5.20 | 1.61–16.87 | 0.006 |
III | 4.89 | 1.56–15.32 | 0.006 | 7.61 | 2.38–24.28 | 0.001 |
IV | 5.00 | 1.59–15.68 | 0.006 | 7.94 | 2.48–25.38 | < 0.001 |
AJCC stage | ||||||
III | Reference | – | – | Reference | – | – |
IV | 1.41 | 1.14–1.73 | 0.001 | 1.36 | 1.11–1.68 | 0.004 |
Chemotherapy | ||||||
No/Unknown | Reference | – | Reference | – | – | |
Yes | 0.48 | 0.36–0.64 | < 0.001 | 0.36 | 0.27–0.48 | < 0.001 |
Surgery | ||||||
No/Unknown | Reference | – | – | Reference | – | – |
Yes | 0.50 | 0.36–0.70 | < 0.001 | 0.61 | 0.44–0.86 | 0.005 |