Table 1 Experimental studies of gingrol in cervical cancer
Form of resveratrol | Doses | Problem | Model | Findings | Ref |
|---|---|---|---|---|---|
(Ginger) 6-gingerol | 50 μM for 24 h | Cervical cancer caused by the human papillomavirus | In vitro [78] | Stopping the progression of cervical cancer by stimulating cell proliferation inhibition and induction of apoptosis | [10] |
(Ginger) 6-gingerol | 50 μM for 24 h | Cervical cancer caused by the human papillomavirus | In vitro [78] | Stopping the progression of cervical cancer by inducing p53-dependent apoptosis independent of HPV oncoproteins (E6 and E7) | [10] |
(Ginger) 6-gingerol | 50 μM for 24 h | Cervical cancer caused by the human papillomavirus | In vitro [78] | Stopping the progression of cervical cancer by stimulating reactivation of p53 through proteasome inhibition | [10] |
(Ginger) 6-gingerol | 50 μM for 24 h | Cervical cancer caused by the human papillomavirus | In vitro [78] | Stopping the progression of cervical cancer by stimulating the production of ROS, DNA damage and reactivating p53 | [10] |
(Ginger) 6-gingerol | 50 μM for 24 h | Cervical cancer caused by the human papillomavirus | In vitro [78] | Stopping the progression of cervical cancer by enhancing the anti-proliferative properties of cisplatin | [10] |
(Ginger) 6-gingerol | 2 and 5 mg/kg bodyweight | Cervical cancer caused by the human papillomavirus | In vivo (mice) | Stopping the progression of cervical cancer by stimulating cell proliferation inhibition and induction of apoptosis | [10] |
(Ginger) 6-shogaol | 15 μM for 24 h | Cervical cancer | In vitro [78] | Stopping the progression of cervical cancer by standing the cell cycle at G2 / M stage through mitochondrial pathways and endoplasmic reticulum stress | [16] |
(Ginger) 1′S-1′-acetoxychavicol acetate or ACA) | 20 μM for Ca Ski and 30 μM for SiHa for 12 h plasmid transfection or 48 h miRNA transfection | Cervical cancer | In vitro (Ca Ski and SiHa) | Stopping the progression of cervical cancer by stimulating apoptosis by inhibiting miR-629 expression and increasing RSU-1 expression conditions in cardiac fibroblasts | [13] |
Zingiber cassumunar Roxb | 56.12 + 0.21 μg/ml cytotoxicity, 7.45 + 0.01 μg/ml PGE2 inhibitor | Women’s Health Remedy (cevical cancer) | In vitro [78] | Stopping the progression of cervical cancer by Cytotoxicity function and suppressing cell proliferation by inhibiting the production of prostaglandins | [92] |
Zingiber officinale Roscoe | 42.07 + 2.01 μg/ml cytotoxicity, 4.78 + 1.60 μg/ml PGE2 inhibitor | Women’s Health Remedy (cevical cancer) | In vitro [78] | Stopping the progression of cervical cancer by Cytotoxicity function and suppressing cell proliferation by inhibiting the production of prostaglandins | [92] |
Zingiber zerumbet (Linn) Smith | 4.42 + 0.20 μg/ml cytotoxicity, 11.34 + 0.28 μg/ml PGE2 inhibitor | Women’s Health Remedy (cevical cancer) | In vitro [78] | Stopping the progression of cervical cancer by Cytotoxicity function and suppressing cell proliferation by inhibiting the production of prostaglandins | [92] |
Alpinia pahangensis | 1, 10, 50, 100 μg/ml for 72 h | Cervical cancer | In vitro (Ca Ski) | Stopping the progression of cervical cancer with antioxidant and cytotoxic properties | [76] |
Zingiber officinale | 12.5, 25, 50 and 100 μg/mL for 24 h | Cervical and breast cancers | In vitro [78] | Stopping the progression of cervical cancer with antioxidant and cytotoxic properties | [18] |
Tongling White Ginger (10-gingerol) | 30 μM for 60 h | Cervical cancer | In vitro [78] | Stopping the progression of cervical cancer by inducing apoptosis through altering cell morphology | [85] |
Tongling White Ginger (10-gingerol) | 30 μM for 60 h | Cervical cancer | In vitro [78] | Stopping the progression of cervical cancer by stanging the cell cycle in stage G0 / G1 | [85] |
Tongling White Ginger (10-gingerol) | 30 μM for 60 h | Cervical cancer | In vitro [78] | Stopping the progression of cervical cancer by stimulating apoptosis | [85] |
Tongling White Ginger (10-gingerol) | 30 μM for 60 h | Cervical cancer | In vitro [78] | Stopping the progression of cervical cancer by inhibiting cell proliferation by suppressing the PI3K / Akt pathway | [85] |