Fig. 2

Waterfall plot of 13 evaluable patients with exploratory therapy. Note: Tumor burden change per investigator review. Maximum reduction from baseline (or smallest increase from baseline for patients with no reductions) in the sum of the longest diameters of target lesions. The change from baseline in tumor measurement as assessed by investigator review is shown for 13 evaluable patients (per protocol set). Front-line exploratory subgroup and multi-line exploratory subgroup were shown with different color in the figure. Among them, there were 3 HRD-positive patients, 6 HRD-negative patients and 4 HRD-unknown patients. Ten of them were treated by niraparib monotherapy while 3 of them (patient 1,7,11) were treated by combined strategies. The dotted line represents the threshold for partial response (> 30% reduction from baseline sum of longest diameters) and progressive disease (> 20% increase from baseline sum of longest diameters). Target lesions were defined according to RECIST 1.1