Table 1 Demographics and cancer history according to gene
Characteristic | BRIP1 | RAD51C | RAD51D | BRCA1 | BRCA2 | PV-Negative |
|---|---|---|---|---|---|---|
Full Testing Cohort (N = 631,950) | ||||||
N | 1779 | 855 | 455 | 7114 | 7940 | 592,309 |
% of Full Testing Cohort | 0.3% | 0.1% | 0.1% | 1.1% | 1.3% | 93.7% |
Subset of Women with Ovarian Cancer (N = 27,915) | ||||||
N | 233 | 149 | 74 | 975 | 723 | 24,468 |
% of Women with Ovarian Cancer | 0.8% | 0.5% | 0.3% | 3.5% | 2.6% | 88.7% |
Self-Reported Ancestry, N (% of PV Carriers) | ||||||
White/Non-Hispanica | 1165 (0.3%) | 492 (0.1%) | 245 (0.1%) | 3863 (1.0%) | 4514 (1.2%) | 354,404 (93.6%) |
Asian | 24 (0.2%) | 24 (0.2%) | 28 (0.2%) | 249 (1.7%) | 270 (1.9%) | 13,577 (93.1%) |
Black/African | 110 (0.2%) | 82 (0.2%) | 55 (0.1%) | 645 (1.2%) | 799 (1.5%) | 48,960 (94.4%) |
Hispanic/Latino | 99 (0.2%) | 80 (0.2%) | 29 (0.1%) | 854 (1.8%) | 662 (1.4%) | 44,276 (93.4%) |
Otherb | 37 (0.3%) | 12 (0.1%) | 13 (0.1%) | 131 (1.1%) | 142 (1.2%) | 11,595 (94.3%) |
Multiple | 80 (0.2%) | 51 (0.2%) | 23 (0.1%) | 352 (1.0%) | 399 (1.2%) | 31,894 (94.2%) |
None Specified | 264 (0.3%) | 114 (0.1%) | 62 (0.1%) | 1020 (1.1%) | 1154 (1.2%) | 87,603 (93.8%) |
History of Ovarian Cancer, N (% of PV Carriers) | ||||||
Personal History of Ovarian Cancer | 233 (13.1%) | 149 (17.4%) | 74 (16.3%) | 975 (13.7%) | 723 (9.1%) | 24,768 (4.2%) |
Family History of Ovarian Cancer | 609 (34.2%) | 283 (33.1%) | 157 (34.5%) | 2496 (35.1%) | 2202 (27.7%) | 169,680 (28.6%) |