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Table 1 Reported cases of nongestational pure choriocarcinoma of the ovary with distant metastases at the time of diagnosis

From: A poor prognostic metastatic nongestational choriocarcinoma of the ovary: a case report and the literature review

Case Authors (Ref) Age Side Distant metastases hCG (IU/L) Surgery Chemotherapy Outcome DNA analysis
1 Stevens et al., 1979 [21] 19 left lung 80,000-160,000 TAH, BSO MA, thiotepa Died No
2 Raju et al., 1985 [22] 16 right lung NS not done not done Died No
3 Tsujioka et al., 2003 [23] 19 left lung 110,000 LSO, OM EMA/CO NED Yes
4 Park et al., 2009 [24] 55 right lung 64,838 TAH, BSO BEP NED No
5 Gremeau et al., 2010 [25] 46 left brain, lung 4,962 LSO YES, details NS Died No
6 Exman et al., 2013 [26] 24 NS lung 675,713 TAH, BSO, OM BEP NED Yes
7 Rao et al., 2015 [27] 26 right spleen, adrenal gland 8,160 RSO, OM, tumor resection of the spleen and adrenal gland BEV NED No
8 Nishino et al., 2020 (present) 38 left brain, lung 5,030 TAH, BSO, tumor resection of the lung MEA, BEP, etc Died Yes
  1. NS not stated, TAH Total abdominal hysterectomy,  SO salpingo-oophorectomy, bilateral, left, right, OM omentectomy
  2. MA methotrexate and actinomycin-D, EMA/CO etoposide, methotrexate, actinomycin-D, cyclophosphamide and vincristine
  3. BEP bleomycin, etoposide, and cisplatin, BEV bleomycin, etoposide, and vincristine, MEA methotrexate, etoposide, and actinomycin-D