A poor prognostic metastatic nongestational choriocarcinoma of the ovary: a case report and the literature review

Table 1 Reported cases of nongestational pure choriocarcinoma of the ovary with distant metastases at the time of diagnosis

Case	Authors (Ref)	Age	Side	Distant metastases	hCG (IU/L)	Surgery	Chemotherapy	Outcome	DNA analysis
1	Stevens et al., 1979 [21]	19	left	lung	80,000-160,000	TAH, BSO	MA, thiotepa	Died	No
2	Raju et al., 1985 [22]	16	right	lung	NS	not done	not done	Died	No
3	Tsujioka et al., 2003 [23]	19	left	lung	110,000	LSO, OM	EMA/CO	NED	Yes
4	Park et al., 2009 [24]	55	right	lung	64,838	TAH, BSO	BEP	NED	No
5	Gremeau et al., 2010 [25]	46	left	brain, lung	4,962	LSO	YES, details NS	Died	No
6	Exman et al., 2013 [26]	24	NS	lung	675,713	TAH, BSO, OM	BEP	NED	Yes
7	Rao et al., 2015 [27]	26	right	spleen, adrenal gland	8,160	RSO, OM, tumor resection of the spleen and adrenal gland	BEV	NED	No
8	Nishino et al., 2020 (present)	38	left	brain, lung	5,030	TAH, BSO, tumor resection of the lung	MEA, BEP, etc	Died	Yes

NS not stated, TAH Total abdominal hysterectomy, SO salpingo-oophorectomy, B bilateral, L left, R right, OM omentectomy
MA methotrexate and actinomycin-D, EMA/CO etoposide, methotrexate, actinomycin-D, cyclophosphamide and vincristine
BEP bleomycin, etoposide, and cisplatin, BEV bleomycin, etoposide, and vincristine, MEA methotrexate, etoposide, and actinomycin-D

ISSN: 1757-2215