Fig. 5From: Activation of SphK1 by adipocytes mediates epithelial ovarian cancer cell proliferationModel of adipocyte-induced EOC cell proliferation through the SphK1-S1PR1/3 signalling pathway. Adipocytes induce ERK-dependent activation of SphK1, release of S1P and the consequent activation of S1PR1/3, leading to ERK phosphorylation and EOC cell proliferation. SphK1 or S1PR1/3 depletion inhibits adipocyte-induced EOC growthBack to article page