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Fig. 4 | Journal of Ovarian Research

Fig. 4

From: Evaluation of mitochondria in mouse oocytes following cisplatin exposure

Fig. 4

Mitochondria in mature oocytes (2 mg/kg cisplatin injected at PN10). Mice were untreated (controls) or 2 mg/kg cisplatin at PN9-11 and then allowed to develop to sexual maturity before being super ovulated. a Number of oocytes harvested from 2 mg/kg cisplatin treated mice. Each dot represents one animal, animal number n = 5/16 control and 2 mg/kg cisplatin treated groups respectively. b Number of oocytes harvested from 4 mg/kg cisplatin treated mice. Each dot represents one animal, N = 3/11 for control and 4 mg/kg cisplatin treated groups, respectively. c Representative confocal images of mature oocytes (BF; bright field) stained with Mitotracker and TMRM. Scale bar = 50 μm. d Relative MitoTracker intensity of mature oocytes from control mice (n = 35 oocytes) and cisplatin treated mice (n = 37 oocytes). e TMRM to MitoTracker ratio of mature oocytes from control mice (n = 35 oocytes) and cisplatin treated mice (n = 37 oocytes). f ATP content in mature oocytes. N = 3/3 from control and cisplatin treated groups respectively. t-test, *p-value < 0.05, **p-value < 0.01

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