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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: RETRACTED ARTICLE: H3K27ac-induced lncRNA PAXIP1-AS1 promotes cell proliferation, migration, EMT and apoptosis in ovarian cancer by targeting miR-6744-5p/PCBP2 axis

Fig. 2

Transcriptional upregulation of PAXIP1-AS1 in OC via CBP-modulated K3K27ac. a UCSC predicted H3K27ac enrichment at PAXIP1-AS1 promoter. b H3K27ac level on PAXIP1-AS1 promoter in HOSEpiC, SKOV3 and OVCAR3 cells was determined by ChIP assay. c PAXIP1-AS1 expression in SKOV3 and OVCAR3 cells treated with DMSO or C646 was confirmed by RT-qPCR. d RT-qPCR results of CBP expression in OC cell lines and HOSEpiC cell line. e Binding of CBP on PAXIP1-AS1 promoter was detected via ChIP assay. f RT-qPCR analysis of CBP silencing in SKOV3 and OVCAR3 cells. g ChIP assay determined the effect of CBP knockdown on H3K27ac at PAXIP1-AS1 promoter. h PAXIP1-AS1 expression upon CBP deficiency in SKOV3 and OVCAR3 cells was assessed by RT-qPCR. *p < 0.05

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Journal of Ovarian Research

ISSN: 1757-2215

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