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Table 2 Meta-analysis of ERCC1 rs11615 polymorphism and chemosensitivity of ovarian cancer (subgroup analysis by ethnicity and HWE)

From: ERCC1 rs11615 polymorphism and chemosensitivity to platinum drugs in patients with ovarian cancer: a systematic review and meta-analysis

Genetic models Subgroup n OR 95%CI Pr I2 (%) Ph Model Pb (Egger’s Test)
C vs.T Overall 10 0.92 0.68 ~ 1.24 0.574 66.4 0.002 REM 0.006
 Ethnicity Asian 5 0.70 0.51 ~ 0.95 0.021 57.7 0.051 REM 0.048
Caucasian 5 1.26 0.85 ~ 1.85 0.246 29.0 0.228 FEM 0.463
 HWE Yes 7 1.12 0.73 ~ 1.73 0.601 73.9 0.001 REM 0.014
No 3 0.65 0.49 ~ 0.87 0.003 0.0 0.433 FEM 0.557
CC + CT vs. TT Overall 10 0.59 0.27 ~ 1.31 0.194 77.0 0.000 REM 0.165
 Ethnicity Asian 5 0.20 0.07 ~ 0.56 0.002 63.6 0.027 REM 0.315
Caucasian 5 1.32 0.75 ~ 2.33 0.342 24.1 0.261 FEM 0.221
 HWE Yes 7 0.87 0.36 ~ 2.08 0.750 75.9 0.000 REM 0.060
No 3 0.18 0.02 ~ 1.63 0.127 83.9 0.002 REM 0.260
CC vs. CT + TT Overall 10 0.85 0.69 ~ 1.05 0.138 28.7 0.181 FEM 0.011
 Ethnicity Asian 5 0.79 0.63 ~ 1.00 0.046 38.7 0.163 FEM 0.052
Caucasian 5 1.23 0.74 ~ 2.05 0.416 0.0 0.501 FEM 0.351
 HWE Yes 7 0.90 0.70 ~ 1.17 0.432 44.0 0.098 FEM 0.010
No 3 0.75 0.52 ~ 1.10 0.139 0.0 0.522 FEM 0.674
CC vs. TT Overall 10 0.62 0.26 ~ 1.48 0.281 75.1 0.000 REM 0.054
 Ethnicity Asian 5 0.21 0.07 ~ 0.59 0.003 63.3 0.028 REM 0.279
Caucasian 5 1.51 0.83 ~ 2.73 0.175 0.0 0.461 FEM 0.230
 HWE Yes 7 1.04 0.39 ~ 2.82 0.935 75.1 0.000 REM 0.014
No 3 0.16 0.02 ~ 1.08 0.059 76.2 0.015 REM 0.305
CT vs. TT Overall 10 0.56 0.25 ~ 1.27 0.163 74.4 0.000 REM 0.269
 Ethnicity Asian 5 0.19 0.07 ~ 0.54 0.002 62.1 0.032 REM 0.436
Caucasian 5 1.32 0.70 ~ 2.47 0.392 24.0 0.262 FEM 0.280
 HWE Yes 7 0.76 0.33 ~ 1.77 0.529 70.3 0.003 REM 0.147
No 3 0.20 0.02 ~ 2.37 0.201 85.8 0.001 REM 0.350
  1. OR Odds ratio, HWE Hardy–Weinberg equilibrium, REM Random-effects model, FEM Fixed-effects model, Pr P for OR, Ph P for Heterogeneity, Pb P for Publication bias