ERCC1 rs11615 polymorphism and chemosensitivity to platinum drugs in patients with ovarian cancer: a systematic review and meta-analysis

Table 2 Meta-analysis of ERCC1 rs11615 polymorphism and chemosensitivity of ovarian cancer (subgroup analysis by ethnicity and HWE)

Genetic models	Subgroup	n	OR	95%CI	P_r	I² (%)	P_h	Model	P_b (Egger’s Test)
C vs.T	Overall	10	0.92	0.68 ~ 1.24	0.574	66.4	0.002	REM	0.006
Ethnicity	Asian	5	0.70	0.51 ~ 0.95	0.021	57.7	0.051	REM	0.048
Ethnicity	Caucasian	5	1.26	0.85 ~ 1.85	0.246	29.0	0.228	FEM	0.463
HWE	Yes	7	1.12	0.73 ~ 1.73	0.601	73.9	0.001	REM	0.014
HWE	No	3	0.65	0.49 ~ 0.87	0.003	0.0	0.433	FEM	0.557
CC + CT vs. TT	Overall	10	0.59	0.27 ~ 1.31	0.194	77.0	0.000	REM	0.165
Ethnicity	Asian	5	0.20	0.07 ~ 0.56	0.002	63.6	0.027	REM	0.315
Ethnicity	Caucasian	5	1.32	0.75 ~ 2.33	0.342	24.1	0.261	FEM	0.221
HWE	Yes	7	0.87	0.36 ~ 2.08	0.750	75.9	0.000	REM	0.060
HWE	No	3	0.18	0.02 ~ 1.63	0.127	83.9	0.002	REM	0.260
CC vs. CT + TT	Overall	10	0.85	0.69 ~ 1.05	0.138	28.7	0.181	FEM	0.011
Ethnicity	Asian	5	0.79	0.63 ~ 1.00	0.046	38.7	0.163	FEM	0.052
Ethnicity	Caucasian	5	1.23	0.74 ~ 2.05	0.416	0.0	0.501	FEM	0.351
HWE	Yes	7	0.90	0.70 ~ 1.17	0.432	44.0	0.098	FEM	0.010
HWE	No	3	0.75	0.52 ~ 1.10	0.139	0.0	0.522	FEM	0.674
CC vs. TT	Overall	10	0.62	0.26 ~ 1.48	0.281	75.1	0.000	REM	0.054
Ethnicity	Asian	5	0.21	0.07 ~ 0.59	0.003	63.3	0.028	REM	0.279
Ethnicity	Caucasian	5	1.51	0.83 ~ 2.73	0.175	0.0	0.461	FEM	0.230
HWE	Yes	7	1.04	0.39 ~ 2.82	0.935	75.1	0.000	REM	0.014
HWE	No	3	0.16	0.02 ~ 1.08	0.059	76.2	0.015	REM	0.305
CT vs. TT	Overall	10	0.56	0.25 ~ 1.27	0.163	74.4	0.000	REM	0.269
Ethnicity	Asian	5	0.19	0.07 ~ 0.54	0.002	62.1	0.032	REM	0.436
Ethnicity	Caucasian	5	1.32	0.70 ~ 2.47	0.392	24.0	0.262	FEM	0.280
HWE	Yes	7	0.76	0.33 ~ 1.77	0.529	70.3	0.003	REM	0.147
HWE	No	3	0.20	0.02 ~ 2.37	0.201	85.8	0.001	REM	0.350

OR Odds ratio, HWE Hardy–Weinberg equilibrium, REM Random-effects model, FEM Fixed-effects model, P_r P for OR, P_h P for Heterogeneity, P_b P for Publication bias

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