Table 4 Adverse events due to chemotherapy according to tomographic response to neoadjuvant chemotherapy (n = 53). Percentage values are calculated within groups
Adverse event (CTCAE 5.0) | With response (%) | Without response (%) | p-valuea | |
|---|---|---|---|---|
Neutropenia | Grade 0 | 10 (31.3) | 4 (19.0) | 0.582 |
Grade 1 | 1 (3.1) | 2 (9.52) | ||
Grade 2 | 8 (25.0) | 8 (38.1) | ||
Grade 3 | 11 (34.4) | 5 (23.9) | ||
Grade 4 | 2 (6.3) | 2 (9.5) | ||
Anemia | Grade 0 | 19 (35.8) | 12 (22.6) | 0.773 |
Grade 1 | 5 (9.4) | 2 (3.8) | ||
Grade 2 | 7 (13.2) | 5 (9.4) | ||
Grade 3 | 1 (1.9) | 2 (3.8) | ||
Thrombocytopenia | Grade 0 | 29 (90.6) | 15 (71.42) | 0.134 |
Grade 1 | 2 (6.2) | 1 (4.8) | ||
Grade 2 | 0 (0.0) | 3 (14.3) | ||
Grade 3 | 1 (3.1) | 2 (9.5) | ||
Nausea | Grade 0 | 19 (57.6) | 11 (52.4) | 0.953 |
Grade 1 | 9 (27.3) | 7 (33.3) | ||
Grade 2 | 4 (12.1) | 3 (14.3) | ||
Grade 3 | 1 (3.0) | 0 (0.0) | ||
Emesis | Grade 0 | 26 (81.2) | 15 (71.4) | 0.676 |
Grade 1 | 4 (12.5) | 5 (23.8) | ||
Grade 2 | 2 (6.3) | 1 (4.8) | ||
Diarrhea | Grade 0 | 27 (84.4) | 20 (95.2) | 0.781 |
Grade 1 | 4 (12.5) | 1 (4.8) | ||
Grade 2 | 1 (3.1) | 0 (0.0) | ||
Renal toxicity | Yes | 1 (3.1) | 0 (0.0) | 1 |
No | 31 (96.9) | 21 (100.0) | ||
Liver Toxicity | Yes | 1 (3.1) | 0 (0.0) | 0.413 |
No | 31 (96.9) | 21 (100.0) | ||
Peripheral | Grade 0 | 23 (71.9) | 14 (66.7) | 0.908 |
Neuropathy | Grade 1 | 5 (15.6) | 3 (14.3) | |
Grade 2 | 4 (12.5) | 4 (19.0) | ||