|
Adverse event (CTCAE 5.0)
|
With response (%)
|
Without response (%)
|
p-valuea
|
|---|
|
Neutropenia
|
Grade 0
|
10 (31.3)
|
4 (19.0)
|
0.582
|
|
Grade 1
|
1 (3.1)
|
2 (9.52)
|
|
Grade 2
|
8 (25.0)
|
8 (38.1)
|
|
Grade 3
|
11 (34.4)
|
5 (23.9)
|
|
Grade 4
|
2 (6.3)
|
2 (9.5)
|
|
Anemia
|
Grade 0
|
19 (35.8)
|
12 (22.6)
|
0.773
|
|
Grade 1
|
5 (9.4)
|
2 (3.8)
|
|
Grade 2
|
7 (13.2)
|
5 (9.4)
|
|
Grade 3
|
1 (1.9)
|
2 (3.8)
|
|
Thrombocytopenia
|
Grade 0
|
29 (90.6)
|
15 (71.42)
|
0.134
|
|
Grade 1
|
2 (6.2)
|
1 (4.8)
|
|
Grade 2
|
0 (0.0)
|
3 (14.3)
|
|
Grade 3
|
1 (3.1)
|
2 (9.5)
|
|
Nausea
|
Grade 0
|
19 (57.6)
|
11 (52.4)
|
0.953
|
|
Grade 1
|
9 (27.3)
|
7 (33.3)
|
|
Grade 2
|
4 (12.1)
|
3 (14.3)
|
|
Grade 3
|
1 (3.0)
|
0 (0.0)
|
|
Emesis
|
Grade 0
|
26 (81.2)
|
15 (71.4)
|
0.676
|
|
Grade 1
|
4 (12.5)
|
5 (23.8)
|
|
Grade 2
|
2 (6.3)
|
1 (4.8)
|
|
Diarrhea
|
Grade 0
|
27 (84.4)
|
20 (95.2)
|
0.781
|
|
Grade 1
|
4 (12.5)
|
1 (4.8)
|
|
Grade 2
|
1 (3.1)
|
0 (0.0)
|
|
Renal toxicity
|
Yes
|
1 (3.1)
|
0 (0.0)
|
1
|
|
No
|
31 (96.9)
|
21 (100.0)
|
|
Liver Toxicity
|
Yes
|
1 (3.1)
|
0 (0.0)
|
0.413
|
|
No
|
31 (96.9)
|
21 (100.0)
|
|
Peripheral
|
Grade 0
|
23 (71.9)
|
14 (66.7)
|
0.908
|
|
Neuropathy
|
Grade 1
|
5 (15.6)
|
3 (14.3)
|
|
Grade 2
|
4 (12.5)
|
4 (19.0)
|
- a Fisher exact test; CTCAE 5.0: Common Terminology Criteria for Adverse Events version 5.0
