Pharmacological inhibition of the PI3K/PTEN/Akt and mTOR signalling pathways limits follicle activation induced by ovarian cryopreservation and in vitro culture

Table 2 Mean number of follicles after in vitro organotypic culture of cryopreserved whole ovaries in presence of pharmacological inhibitors

Ovaries from Nu/Nu mice, 4-weeks old, n = 5 ovaries per group
Results are expressed in percentage of primordial, primary and secondary or more mature follicles relative to the total number of follicles present in one ovarian slide. Mean ± SEM
CT Control, LY LY294002, Ra Rapamycin
^adifferent from CT, ^bdifferent from Ra

ISSN: 1757-2215