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Table 2 Mean number of follicles after in vitro organotypic culture of cryopreserved whole ovaries in presence of pharmacological inhibitors

From: Pharmacological inhibition of the PI3K/PTEN/Akt and mTOR signalling pathways limits follicle activation induced by ovarian cryopreservation and in vitro culture

  CT LY Ra
24 h
 Primordial 20.53 ± 1.906 21.22 ± 1.584b 26.81 ± 1.516a
 Primary 16.61 ± 3.265 8.993 ± 2.302 7.72 ± 1.348
 Secondary or more 42.37 ± 2.56 48.65 ± 3.192b 38.73 ± 2.397
  1. Ovaries from Nu/Nu mice, 4-weeks old, n = 5 ovaries per group
  2. Results are expressed in percentage of primordial, primary and secondary or more mature follicles relative to the total number of follicles present in one ovarian slide. Mean ± SEM
  3. CT Control, LY LY294002, Ra Rapamycin
  4. adifferent from CT, bdifferent from Ra
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Journal of Ovarian Research

ISSN: 1757-2215

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